Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism
Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) (poly(NIPAAm-co-NVP)) with a co-monomer molar ratio in copolymer of 91.5/8.5 (NIPAAm/NVP) was synthesized as an interesting thermosensitive material possessing a sharp phase transition at 36 °C under simulated physiological conditions. The effect of...
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| Format: | Article |
| Language: | English |
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Budapest University of Technology and Economics
2020-01-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0010125&mi=cd |
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| author | G. Fundueanu M. Constantin S. Bucatariu P. Ascenzi |
| author_facet | G. Fundueanu M. Constantin S. Bucatariu P. Ascenzi |
| author_sort | G. Fundueanu |
| collection | DOAJ |
| description | Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) (poly(NIPAAm-co-NVP)) with a co-monomer molar ratio in copolymer of 91.5/8.5 (NIPAAm/NVP) was synthesized as an interesting thermosensitive material possessing a sharp phase transition at 36 °C under simulated physiological conditions. The effect of the co-monomer molar ratio as well as of the ionic strength and nature of ions on the lower critical solution temperature (LCST) was investigated. Cross-linked poly(NIPAAm-co-NVP) thermoresponsive microspheres were synthesized by the suspension polymerization technique respecting the same NIPAAm/NVP molar ratio as for linear polymer. The microspheres were loaded with the model drug diclofenac (DF) by the solvent evaporation method; differential scanning calorimetry (DSC) demonstrates a dispersion of drug crystals within the polymeric matrix. The DF release rate is deeply influenced by the drug loading degree. Only microspheres with low DF loading are able to release the bioactive compound through a pulsatile mechanism. |
| format | Article |
| id | doaj-art-11f182eebcff4f56928905bcff6ebacb |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-11f182eebcff4f56928905bcff6ebacb2025-08-20T03:32:55ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2020-01-01141637610.3144/expresspolymlett.2020.6Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanismG. FundueanuM. ConstantinS. BucatariuP. AscenziPoly(N-isopropylacrylamide-co-N-vinylpyrrolidone) (poly(NIPAAm-co-NVP)) with a co-monomer molar ratio in copolymer of 91.5/8.5 (NIPAAm/NVP) was synthesized as an interesting thermosensitive material possessing a sharp phase transition at 36 °C under simulated physiological conditions. The effect of the co-monomer molar ratio as well as of the ionic strength and nature of ions on the lower critical solution temperature (LCST) was investigated. Cross-linked poly(NIPAAm-co-NVP) thermoresponsive microspheres were synthesized by the suspension polymerization technique respecting the same NIPAAm/NVP molar ratio as for linear polymer. The microspheres were loaded with the model drug diclofenac (DF) by the solvent evaporation method; differential scanning calorimetry (DSC) demonstrates a dispersion of drug crystals within the polymeric matrix. The DF release rate is deeply influenced by the drug loading degree. Only microspheres with low DF loading are able to release the bioactive compound through a pulsatile mechanism.http://www.expresspolymlett.com/letolt.php?file=EPL-0010125&mi=cdsmart polymerspoly(n-isopropylacrylamide)drug deliverymicrospheresstimuli-sensitive polymers |
| spellingShingle | G. Fundueanu M. Constantin S. Bucatariu P. Ascenzi Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism eXPRESS Polymer Letters smart polymers poly(n-isopropylacrylamide) drug delivery microspheres stimuli-sensitive polymers |
| title | Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism |
| title_full | Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism |
| title_fullStr | Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism |
| title_full_unstemmed | Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism |
| title_short | Poly(N-isopropylacrylamide-co-N-vinylpyrrolidone) thermoresponsive microspheres: The low drug loading ensures the pulsatile release mechanism |
| title_sort | poly n isopropylacrylamide co n vinylpyrrolidone thermoresponsive microspheres the low drug loading ensures the pulsatile release mechanism |
| topic | smart polymers poly(n-isopropylacrylamide) drug delivery microspheres stimuli-sensitive polymers |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0010125&mi=cd |
| work_keys_str_mv | AT gfundueanu polynisopropylacrylamideconvinylpyrrolidonethermoresponsivemicrospheresthelowdrugloadingensuresthepulsatilereleasemechanism AT mconstantin polynisopropylacrylamideconvinylpyrrolidonethermoresponsivemicrospheresthelowdrugloadingensuresthepulsatilereleasemechanism AT sbucatariu polynisopropylacrylamideconvinylpyrrolidonethermoresponsivemicrospheresthelowdrugloadingensuresthepulsatilereleasemechanism AT pascenzi polynisopropylacrylamideconvinylpyrrolidonethermoresponsivemicrospheresthelowdrugloadingensuresthepulsatilereleasemechanism |