Imiquimod, a Promising Broad-Spectrum Antiviral, Prevents SARS-CoV-2 and Canine Coronavirus Multiplication Through the MAPK/ERK Signaling Pathway

Imiquimod, a Promising Broad-Spectrum Antiviral, Prevents SARS-CoV-2 and Canine Coronavirus Multiplication Through the MAPK/ERK Signaling Pathway

Respiratory viruses can cause life-threatening conditions such as sepsis and acute respiratory distress syndrome. However, vaccines and effective antivirals are available for only a limited number of infections. The majority of approved antivirals are direct-acting agents, which target viral protein...

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Bibliographic Details
Main Authors: Josefina Vicente, Freddy Armando Peñaranda Figueredo, Stefania Mantovani, Daniela Laura Papademetrio, Sergio Ivan Nemirovsky, Andrea Alejandra Barquero, Carina Shayo, Carlos Alberto Bueno
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Viruses
Subjects:
SARS-CoV-2
canine coronavirus
broad-spectrum antiviral
imiquimod
ERK
Toll-like receptors (TLRs)
Online Access:https://www.mdpi.com/1999-4915/17/6/801
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