Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis
Abstract Screening is effective in reducing the disease burden of colorectal cancer, with participation and coverage rates being key determinants of its effectiveness. This systematic review aims to provide a comprehensive assessment of colorectal cancer screening program characteristics and global...
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| Language: | English |
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BMC
2025-07-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06887-4 |
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| author | Yuqing Chen Yuelun Zhang Yike Yan Jingjing Han Li Zhang Xinran Cheng Bin Lu Na Li Chenyu Luo Yueyang Zhou Kai Song Motoki Iwasaki Min Dai Dong Wu Hongda Chen |
| author_facet | Yuqing Chen Yuelun Zhang Yike Yan Jingjing Han Li Zhang Xinran Cheng Bin Lu Na Li Chenyu Luo Yueyang Zhou Kai Song Motoki Iwasaki Min Dai Dong Wu Hongda Chen |
| author_sort | Yuqing Chen |
| collection | DOAJ |
| description | Abstract Screening is effective in reducing the disease burden of colorectal cancer, with participation and coverage rates being key determinants of its effectiveness. This systematic review aims to provide a comprehensive assessment of colorectal cancer screening program characteristics and global screening coverage rates. We conducted a systematic literature search in the PubMed and Embase databases from inception to March 2025. Grey literature was obtained from screening program websites and relevant reports. Studies reporting nationwide colorectal cancer screening coverage were eligible for our analysis. A comprehensive overview of essential information and the most recent coverage rates for global screening programs were reported. Temporal trend analyses of coverage rates and subgroup analyses by sex and age were performed. Our results encompassed 45 countries with established national screening programs, among which 33 of them having retrieved coverage rates. Population-based screening programs were predominantly conducted in Europe (25/39), with fecal occult blood testing being the most commonly used modality (38/39). The reported latest screening coverage rates varied greatly across countries, ranging from 1.0% (China, 2020) to 79.4% (Finland, 2021). The coverage of screening program differed slightly between men and women in most countries (men: IQR, 25.3–52.7%; women: IQR, 23.0–65.1%), and coverage increased with age. Temporal trend analysis in 14 countries showed that the majority exhibited increasing or stable screening coverage rates. These findings highlight significant disparities in CRC screening implementation worldwide. Targeted efforts to improve participation and expand coverage are essential, particularly in countries with a high disease burden. |
| format | Article |
| id | doaj-art-11edf9a85d4842a397c428f07db384c2 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-11edf9a85d4842a397c428f07db384c22025-08-20T03:46:19ZengBMCJournal of Translational Medicine1479-58762025-07-0123111210.1186/s12967-025-06887-4Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesisYuqing Chen0Yuelun Zhang1Yike Yan2Jingjing Han3Li Zhang4Xinran Cheng5Bin Lu6Na Li7Chenyu Luo8Yueyang Zhou9Kai Song10Motoki Iwasaki11Min Dai12Dong Wu13Hongda Chen14Center for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical CollegeSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDivision of Epidemiology, National Cancer Center Institute for Cancer ControlDepartment of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Screening is effective in reducing the disease burden of colorectal cancer, with participation and coverage rates being key determinants of its effectiveness. This systematic review aims to provide a comprehensive assessment of colorectal cancer screening program characteristics and global screening coverage rates. We conducted a systematic literature search in the PubMed and Embase databases from inception to March 2025. Grey literature was obtained from screening program websites and relevant reports. Studies reporting nationwide colorectal cancer screening coverage were eligible for our analysis. A comprehensive overview of essential information and the most recent coverage rates for global screening programs were reported. Temporal trend analyses of coverage rates and subgroup analyses by sex and age were performed. Our results encompassed 45 countries with established national screening programs, among which 33 of them having retrieved coverage rates. Population-based screening programs were predominantly conducted in Europe (25/39), with fecal occult blood testing being the most commonly used modality (38/39). The reported latest screening coverage rates varied greatly across countries, ranging from 1.0% (China, 2020) to 79.4% (Finland, 2021). The coverage of screening program differed slightly between men and women in most countries (men: IQR, 25.3–52.7%; women: IQR, 23.0–65.1%), and coverage increased with age. Temporal trend analysis in 14 countries showed that the majority exhibited increasing or stable screening coverage rates. These findings highlight significant disparities in CRC screening implementation worldwide. Targeted efforts to improve participation and expand coverage are essential, particularly in countries with a high disease burden.https://doi.org/10.1186/s12967-025-06887-4Colorectal cancerScreeningCoverageSystematic review |
| spellingShingle | Yuqing Chen Yuelun Zhang Yike Yan Jingjing Han Li Zhang Xinran Cheng Bin Lu Na Li Chenyu Luo Yueyang Zhou Kai Song Motoki Iwasaki Min Dai Dong Wu Hongda Chen Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis Journal of Translational Medicine Colorectal cancer Screening Coverage Systematic review |
| title | Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis |
| title_full | Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis |
| title_fullStr | Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis |
| title_full_unstemmed | Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis |
| title_short | Global colorectal cancer screening programs and coverage rate estimation: an evidence synthesis |
| title_sort | global colorectal cancer screening programs and coverage rate estimation an evidence synthesis |
| topic | Colorectal cancer Screening Coverage Systematic review |
| url | https://doi.org/10.1186/s12967-025-06887-4 |
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