Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy.
<h4>Objective</h4>This study aims to explore the expression pattern and prognostic significance of miR-33a in non-small cell lung cancer (NSCLC) treated with adjuvant chemotherapy.<h4>Methods</h4>MiR-33aexpression in NSCLC was analyzed in silico using the GEO database and was...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170431&type=printable |
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| author | Li-Kun Hou Yu-Shui Ma Yang Han Gai-Xia Lu Pei Luo Zheng-Yan Chang Ru-Ting Xie Hui-Qiong Yang Li Chai Ming-Xiang Cai Ting-Miao Wu Fei Yu Shan-Shan Qin Zhong-Wei Lv Chun-Yan Wu Da Fu |
| author_facet | Li-Kun Hou Yu-Shui Ma Yang Han Gai-Xia Lu Pei Luo Zheng-Yan Chang Ru-Ting Xie Hui-Qiong Yang Li Chai Ming-Xiang Cai Ting-Miao Wu Fei Yu Shan-Shan Qin Zhong-Wei Lv Chun-Yan Wu Da Fu |
| author_sort | Li-Kun Hou |
| collection | DOAJ |
| description | <h4>Objective</h4>This study aims to explore the expression pattern and prognostic significance of miR-33a in non-small cell lung cancer (NSCLC) treated with adjuvant chemotherapy.<h4>Methods</h4>MiR-33aexpression in NSCLC was analyzed in silico using the GEO database and was subsequently confirmed by quantitative RT-PCR in 147 NSCLC biopsies. Among these, 32 of these biopsies were paired with adjacent non-neoplastic tissues. The survival analysis of NSCLC by Kaplan-Meier estimates was stratified based on miR-33a expression. In addition, multivariate survival analysis in corresponding groups of NSCLC patients was conducted by Cox proportional hazards regression model.<h4>Results</h4>The in silico analysis of miR-33a expression in NSCLC resulted to its down-regulation in different tumor types. The expression level of miR-33a was lower in each grade of NSCLC tumor biopsies than in normal lung tissues. Univariate and multivariate survival analysis further established that low miR-33a expression was an important risk factor for overall survival and disease free survival in NSCLC patients.<h4>Conclusion</h4>Our study implied that miR-33a expression levels may have an essential role in NSCLC progression, and could act as a specific and sensitive biomarker for NSCLC patients who have undergone adjuvant chemotherapy. |
| format | Article |
| id | doaj-art-11ec4b7dd294447e95547b61fa1b97d6 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-11ec4b7dd294447e95547b61fa1b97d62025-08-20T02:45:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01121e017043110.1371/journal.pone.0170431Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy.Li-Kun HouYu-Shui MaYang HanGai-Xia LuPei LuoZheng-Yan ChangRu-Ting XieHui-Qiong YangLi ChaiMing-Xiang CaiTing-Miao WuFei YuShan-Shan QinZhong-Wei LvChun-Yan WuDa Fu<h4>Objective</h4>This study aims to explore the expression pattern and prognostic significance of miR-33a in non-small cell lung cancer (NSCLC) treated with adjuvant chemotherapy.<h4>Methods</h4>MiR-33aexpression in NSCLC was analyzed in silico using the GEO database and was subsequently confirmed by quantitative RT-PCR in 147 NSCLC biopsies. Among these, 32 of these biopsies were paired with adjacent non-neoplastic tissues. The survival analysis of NSCLC by Kaplan-Meier estimates was stratified based on miR-33a expression. In addition, multivariate survival analysis in corresponding groups of NSCLC patients was conducted by Cox proportional hazards regression model.<h4>Results</h4>The in silico analysis of miR-33a expression in NSCLC resulted to its down-regulation in different tumor types. The expression level of miR-33a was lower in each grade of NSCLC tumor biopsies than in normal lung tissues. Univariate and multivariate survival analysis further established that low miR-33a expression was an important risk factor for overall survival and disease free survival in NSCLC patients.<h4>Conclusion</h4>Our study implied that miR-33a expression levels may have an essential role in NSCLC progression, and could act as a specific and sensitive biomarker for NSCLC patients who have undergone adjuvant chemotherapy.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170431&type=printable |
| spellingShingle | Li-Kun Hou Yu-Shui Ma Yang Han Gai-Xia Lu Pei Luo Zheng-Yan Chang Ru-Ting Xie Hui-Qiong Yang Li Chai Ming-Xiang Cai Ting-Miao Wu Fei Yu Shan-Shan Qin Zhong-Wei Lv Chun-Yan Wu Da Fu Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy. PLoS ONE |
| title | Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy. |
| title_full | Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy. |
| title_fullStr | Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy. |
| title_full_unstemmed | Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy. |
| title_short | Association of microRNA-33a Molecular Signature with Non-Small Cell Lung Cancer Diagnosis and Prognosis after Chemotherapy. |
| title_sort | association of microrna 33a molecular signature with non small cell lung cancer diagnosis and prognosis after chemotherapy |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170431&type=printable |
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