Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor

Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor

Lens epithelium, a fundamental biological structure pivotal for maintaining normal vision, can be disrupted, leading to the development of cataracts. The epithelial-mesenchymal transition has been proven to be the key factor of secondary cataract progression. However, the underlying mechanism of epi...

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Bibliographic Details
Main Authors: Huiping Lu, Xianyang Liu, Qian Zhou, Ruonan Li, Hangjia Zuo, Ke Hu, Meng Tian, Hong Wang, Jianqiao Li, Na Li, Shengping Hou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Genes and Diseases
Subjects:
Activating transcription factor 6
Cataract
Epithelial-mesenchymal transition
Fiber cell
Lens epithelium
Single-cell sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225000996
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http://www.sciencedirect.com/science/article/pii/S2352304225000996

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