From brain collections to modern brain banks: A historical perspective
Abstract Our current knowledge of the structure, function, and diseases of the brain comes from direct examination of its substance. In the last centuries, only a few elite had managed to retrieve, gather, and preserve the elusive brain for their own research. The resulting brain collections, stored...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
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| Online Access: | https://doi.org/10.1016/j.trci.2018.12.002 |
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| author | Arenn Faye Carlos Tino Emanuele Poloni Valentina Medici Maia Chikhladze Antonio Guaita Mauro Ceroni |
| author_facet | Arenn Faye Carlos Tino Emanuele Poloni Valentina Medici Maia Chikhladze Antonio Guaita Mauro Ceroni |
| author_sort | Arenn Faye Carlos |
| collection | DOAJ |
| description | Abstract Our current knowledge of the structure, function, and diseases of the brain comes from direct examination of its substance. In the last centuries, only a few elite had managed to retrieve, gather, and preserve the elusive brain for their own research. The resulting brain collections, stored in formalin‐filled jars or dried up in cabinets, served anatomical, neuropathological, anthropometric, ideological, and diagnostic purposes. In the 1960s, the first modern brain banks actively collecting and strategically preserving both diseased and healthy brains to be consequently distributed to the scientific community were instituted. In an era where state‐of‐the‐art biochemical “Omic” studies and advanced metabolic and molecular neuroimaging exist, it is now, more than ever, that postmortem brain investigations must be performed. Only through the comparison and integration of postmortem neuropathological and biochemical findings and antemortem data from clinical, neuropsychological neuroimaging, and other biomarker examinations can we truly understand neurological disease mechanisms. Brain banks supplying brain specimens, antemortem information, and postmortem diagnosis are a major benefactor of brain research. |
| format | Article |
| id | doaj-art-11dcf5b0b9cb4dd2bc210d49220b48fa |
| institution | OA Journals |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-11dcf5b0b9cb4dd2bc210d49220b48fa2025-08-20T02:36:54ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-0151526010.1016/j.trci.2018.12.002From brain collections to modern brain banks: A historical perspectiveArenn Faye Carlos0Tino Emanuele Poloni1Valentina Medici2Maia Chikhladze3Antonio Guaita4Mauro Ceroni5Neuropathology DepartmentAbbiategrasso Brain BankGolgi‐Cenci Foundation AbbiategrassoMilanItalyNeuropathology DepartmentAbbiategrasso Brain BankGolgi‐Cenci Foundation AbbiategrassoMilanItalyNeuropathology DepartmentAbbiategrasso Brain BankGolgi‐Cenci Foundation AbbiategrassoMilanItalyNeuropathology DepartmentAbbiategrasso Brain BankGolgi‐Cenci Foundation AbbiategrassoMilanItalyNeuropathology DepartmentAbbiategrasso Brain BankGolgi‐Cenci Foundation AbbiategrassoMilanItalyUniversity of PaviaPaviaItalyAbstract Our current knowledge of the structure, function, and diseases of the brain comes from direct examination of its substance. In the last centuries, only a few elite had managed to retrieve, gather, and preserve the elusive brain for their own research. The resulting brain collections, stored in formalin‐filled jars or dried up in cabinets, served anatomical, neuropathological, anthropometric, ideological, and diagnostic purposes. In the 1960s, the first modern brain banks actively collecting and strategically preserving both diseased and healthy brains to be consequently distributed to the scientific community were instituted. In an era where state‐of‐the‐art biochemical “Omic” studies and advanced metabolic and molecular neuroimaging exist, it is now, more than ever, that postmortem brain investigations must be performed. Only through the comparison and integration of postmortem neuropathological and biochemical findings and antemortem data from clinical, neuropsychological neuroimaging, and other biomarker examinations can we truly understand neurological disease mechanisms. Brain banks supplying brain specimens, antemortem information, and postmortem diagnosis are a major benefactor of brain research.https://doi.org/10.1016/j.trci.2018.12.002Brain bankBrain collectionBrain bank networkHistory of brain bankingHistory of neuroscienceBrain archiving |
| spellingShingle | Arenn Faye Carlos Tino Emanuele Poloni Valentina Medici Maia Chikhladze Antonio Guaita Mauro Ceroni From brain collections to modern brain banks: A historical perspective Alzheimer’s & Dementia: Translational Research & Clinical Interventions Brain bank Brain collection Brain bank network History of brain banking History of neuroscience Brain archiving |
| title | From brain collections to modern brain banks: A historical perspective |
| title_full | From brain collections to modern brain banks: A historical perspective |
| title_fullStr | From brain collections to modern brain banks: A historical perspective |
| title_full_unstemmed | From brain collections to modern brain banks: A historical perspective |
| title_short | From brain collections to modern brain banks: A historical perspective |
| title_sort | from brain collections to modern brain banks a historical perspective |
| topic | Brain bank Brain collection Brain bank network History of brain banking History of neuroscience Brain archiving |
| url | https://doi.org/10.1016/j.trci.2018.12.002 |
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