Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol

Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol

Abstract Background Infectious diseases are among the most common causes of hospitalization in older adults and may lead to a high burden on the individual’s health and healthcare system. However, it is unclear whether and to which extent these events might affect frailty, fastening its development...

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Main Authors: Wenxiang Guo, Leonardo Bencivenga, Bruno Micael Zanforlini, Chiara Curreri, Maria Cristina Ferrara, Benedetta Maisano, Luca Tinelli, Laura Andreea Ceparano, Raffaella Merenda, Chiara Cosma, Lucia Manfron, Nicolò Gentili, Silvia Sturani, Monica Cardi, Alice Campion, Benedetta Berardi, Martina Lombardi, Elisabetta D’Aversa, Francesca Salvatori, Veronica Tisato, Joanne Vanessa Vargas, Grazia Daniela Femminella, Donato Gemmati, Giuseppe Sergi, Giuseppe Bellelli, Paolo Mazzola, Caterina Trevisan, Stefano Volpato, the INFRAGEN working group
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Geriatrics
Subjects:
Frailty
Infections
Epigenetic factors
Genetics
Inflammation mediators
Longitudinal study
Online Access:https://doi.org/10.1186/s12877-025-06194-z
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