Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice
Obesity, which is characterized by excessive body fat accumulation and energy imbalance, is a major risk factor for type 2 diabetes mellitus. <i>Boesenbergia rotunda</i> rhizomes (known as fingerroots) exhibit a variety of pharmacological activities and are used in traditional medicine....
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2025-01-01
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| author | Muhammad Hermawan Widyananda Dinia Rizqi Dwijayanti Airi Fujii Keita Minamisaka Yuto Nishidono Mikio Nishizawa Nashi Widodo |
| author_facet | Muhammad Hermawan Widyananda Dinia Rizqi Dwijayanti Airi Fujii Keita Minamisaka Yuto Nishidono Mikio Nishizawa Nashi Widodo |
| author_sort | Muhammad Hermawan Widyananda |
| collection | DOAJ |
| description | Obesity, which is characterized by excessive body fat accumulation and energy imbalance, is a major risk factor for type 2 diabetes mellitus. <i>Boesenbergia rotunda</i> rhizomes (known as fingerroots) exhibit a variety of pharmacological activities and are used in traditional medicine. Pinostrobin was identified as a major constituent of <i>Boesenbergia rotunda</i> rhizome (BR) extract and suppressed nitric oxide production in interleukin 1β-treated hepatocytes. Next, we investigated the anti-obesity effects of BR extract in <i>ob/ob</i> mice, a type 2 diabetes mellitus model. The <i>ob/ob</i> mice were treated with or without 1% BR extract for 14 days and then analyzed for serum insulin and triglyceride levels, liver histology, and liver mRNA expression. The administration of BR extract significantly decreased blood glucose concentrations and increased serum insulin concentrations in <i>ob/ob</i> mice. In addition, this treatment reduced triglyceride levels in both the serum and liver and decreased lipid accumulation in hepatocytes. Microarray analysis revealed that hepatic mRNA affected the expression of genes involved in inflammation, lipid metabolism, lipid synthesis, and insulin signaling, leading to improvements in obesity. Because BR extract has hypoglycemic and antidiabetic effects on <i>ob/ob</i> mice, it might be a promising candidate for addressing obesity and related metabolic disorders. |
| format | Article |
| id | doaj-art-11d9acde21ca4d60bfed6d699fe54b71 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-11d9acde21ca4d60bfed6d699fe54b712025-08-20T02:12:30ZengMDPI AGMolecules1420-30492025-01-0130350110.3390/molecules30030501Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> MiceMuhammad Hermawan Widyananda0Dinia Rizqi Dwijayanti1Airi Fujii2Keita Minamisaka3Yuto Nishidono4Mikio Nishizawa5Nashi Widodo6Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, IndonesiaCollege of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Shiga, JapanCollege of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Shiga, JapanResearch Organization of Science and Technology, Ritsumeikan University, Kusatsu 525-8577, Shiga, JapanDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang 65113, East Java, IndonesiaObesity, which is characterized by excessive body fat accumulation and energy imbalance, is a major risk factor for type 2 diabetes mellitus. <i>Boesenbergia rotunda</i> rhizomes (known as fingerroots) exhibit a variety of pharmacological activities and are used in traditional medicine. Pinostrobin was identified as a major constituent of <i>Boesenbergia rotunda</i> rhizome (BR) extract and suppressed nitric oxide production in interleukin 1β-treated hepatocytes. Next, we investigated the anti-obesity effects of BR extract in <i>ob/ob</i> mice, a type 2 diabetes mellitus model. The <i>ob/ob</i> mice were treated with or without 1% BR extract for 14 days and then analyzed for serum insulin and triglyceride levels, liver histology, and liver mRNA expression. The administration of BR extract significantly decreased blood glucose concentrations and increased serum insulin concentrations in <i>ob/ob</i> mice. In addition, this treatment reduced triglyceride levels in both the serum and liver and decreased lipid accumulation in hepatocytes. Microarray analysis revealed that hepatic mRNA affected the expression of genes involved in inflammation, lipid metabolism, lipid synthesis, and insulin signaling, leading to improvements in obesity. Because BR extract has hypoglycemic and antidiabetic effects on <i>ob/ob</i> mice, it might be a promising candidate for addressing obesity and related metabolic disorders.https://www.mdpi.com/1420-3049/30/3/501hyperglycemiaobesity<i>Boesenbergia rotunda</i>pinostrobinnitric oxideinsulin |
| spellingShingle | Muhammad Hermawan Widyananda Dinia Rizqi Dwijayanti Airi Fujii Keita Minamisaka Yuto Nishidono Mikio Nishizawa Nashi Widodo Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice Molecules hyperglycemia obesity <i>Boesenbergia rotunda</i> pinostrobin nitric oxide insulin |
| title | Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice |
| title_full | Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice |
| title_fullStr | Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice |
| title_full_unstemmed | Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice |
| title_short | Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice |
| title_sort | anti obesity properties of i boesenbergia rotunda i rhizome extract regulation of inflammation lipid metabolism and insulin signaling in i ob ob i mice |
| topic | hyperglycemia obesity <i>Boesenbergia rotunda</i> pinostrobin nitric oxide insulin |
| url | https://www.mdpi.com/1420-3049/30/3/501 |
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