Anti-Obesity Properties of <i>Boesenbergia rotunda</i> Rhizome Extract: Regulation of Inflammation, Lipid Metabolism, and Insulin Signaling in <i>ob/ob</i> Mice
Obesity, which is characterized by excessive body fat accumulation and energy imbalance, is a major risk factor for type 2 diabetes mellitus. <i>Boesenbergia rotunda</i> rhizomes (known as fingerroots) exhibit a variety of pharmacological activities and are used in traditional medicine....
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/3/501 |
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| Summary: | Obesity, which is characterized by excessive body fat accumulation and energy imbalance, is a major risk factor for type 2 diabetes mellitus. <i>Boesenbergia rotunda</i> rhizomes (known as fingerroots) exhibit a variety of pharmacological activities and are used in traditional medicine. Pinostrobin was identified as a major constituent of <i>Boesenbergia rotunda</i> rhizome (BR) extract and suppressed nitric oxide production in interleukin 1β-treated hepatocytes. Next, we investigated the anti-obesity effects of BR extract in <i>ob/ob</i> mice, a type 2 diabetes mellitus model. The <i>ob/ob</i> mice were treated with or without 1% BR extract for 14 days and then analyzed for serum insulin and triglyceride levels, liver histology, and liver mRNA expression. The administration of BR extract significantly decreased blood glucose concentrations and increased serum insulin concentrations in <i>ob/ob</i> mice. In addition, this treatment reduced triglyceride levels in both the serum and liver and decreased lipid accumulation in hepatocytes. Microarray analysis revealed that hepatic mRNA affected the expression of genes involved in inflammation, lipid metabolism, lipid synthesis, and insulin signaling, leading to improvements in obesity. Because BR extract has hypoglycemic and antidiabetic effects on <i>ob/ob</i> mice, it might be a promising candidate for addressing obesity and related metabolic disorders. |
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| ISSN: | 1420-3049 |