Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope

Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope

Abstract Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus that can cause severe encephalitis in humans and horses with a high case fatality rate. There are no licensed EEEV vaccines or therapeutics for human use, warranting the need to better understand the human immune...

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Main Authors: Abhishek Bandyopadhyay, Lauren E. Williamson, Devika Sirohi, Kevin Bailey, Theron Gilliland, Thomas Klose, Geeta Buda, Andrew Trivette, Chengqun Sun, Justin G. Julander, William B. Klimstra, James E. Crowe, Richard J. Kuhn
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60505-x
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