Therapeutic Potential of Exercise-Induced SPARC in Bone Health?
Exploring biological properties leading to potential pharmacological applications has been a fruitful approach in biomedical research. Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among th...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/4/945 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849712417956691968 |
|---|---|
| author | Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand |
| author_facet | Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand |
| author_sort | Abdelaziz Ghanemi |
| collection | DOAJ |
| description | Exploring biological properties leading to potential pharmacological applications has been a fruitful approach in biomedical research. Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among the properties it has, its calcium and collagen binding patterns along with other biochemical, metabolic, and structural effects represent a starting point towards developing therapeutic options based on SPARC properties for bones in pathological, preventive, and regenerative contexts. Such properties can be explored in conditions including bone fractures or requiring bone regenerative adjuvants. In addition, these properties can also be applied in basic research such as building an environment more suitable for cellular proliferation or optimizing in vitro conditions. |
| format | Article |
| id | doaj-art-11d7d82fbdd34e008a6404f11efd00c3 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-11d7d82fbdd34e008a6404f11efd00c32025-08-20T03:14:16ZengMDPI AGBiomedicines2227-90592025-04-0113494510.3390/biomedicines13040945Therapeutic Potential of Exercise-Induced SPARC in Bone Health?Abdelaziz Ghanemi0Mayumi Yoshioka1Jonny St-Amand2Functional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Quebec, QC G1V 4G2, CanadaFunctional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Quebec, QC G1V 4G2, CanadaFunctional Genomics Laboratory, Endocrinology and Nephrology Axis, CHU de Québec-Université Laval Research Center, Quebec, QC G1V 4G2, CanadaExploring biological properties leading to potential pharmacological applications has been a fruitful approach in biomedical research. Secreted protein acidic and rich in cysteine (SPARC) is an exercise-induced glycoprotein known for its functions at different cellular and molecular levels. Among the properties it has, its calcium and collagen binding patterns along with other biochemical, metabolic, and structural effects represent a starting point towards developing therapeutic options based on SPARC properties for bones in pathological, preventive, and regenerative contexts. Such properties can be explored in conditions including bone fractures or requiring bone regenerative adjuvants. In addition, these properties can also be applied in basic research such as building an environment more suitable for cellular proliferation or optimizing in vitro conditions.https://www.mdpi.com/2227-9059/13/4/945secreted protein acidic and rich in cysteine (SPARC)bonetherapy |
| spellingShingle | Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand Therapeutic Potential of Exercise-Induced SPARC in Bone Health? Biomedicines secreted protein acidic and rich in cysteine (SPARC) bone therapy |
| title | Therapeutic Potential of Exercise-Induced SPARC in Bone Health? |
| title_full | Therapeutic Potential of Exercise-Induced SPARC in Bone Health? |
| title_fullStr | Therapeutic Potential of Exercise-Induced SPARC in Bone Health? |
| title_full_unstemmed | Therapeutic Potential of Exercise-Induced SPARC in Bone Health? |
| title_short | Therapeutic Potential of Exercise-Induced SPARC in Bone Health? |
| title_sort | therapeutic potential of exercise induced sparc in bone health |
| topic | secreted protein acidic and rich in cysteine (SPARC) bone therapy |
| url | https://www.mdpi.com/2227-9059/13/4/945 |
| work_keys_str_mv | AT abdelazizghanemi therapeuticpotentialofexerciseinducedsparcinbonehealth AT mayumiyoshioka therapeuticpotentialofexerciseinducedsparcinbonehealth AT jonnystamand therapeuticpotentialofexerciseinducedsparcinbonehealth |