Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability
This comprehensive review explores nanobubbles (NBs) technology advancements for improving drug and nutraceutical delivery and promoting human health. NBs are gas-filled nanocarriers owing to unique structures, excellent stability, flexibility, biocompatibility, and precise targeting abilities that...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Nanotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnano.2025.1548593/full |
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| author | Farhang Hameed Awlqadr Sobia Noreen Sobia Noreen Ammar B. Altemimi Ammar B. Altemimi Othman Abdulrahman Mohammed Syamand Ahmed Qadir Dyari H. Ahmed Zina T. Alkanan Efstathia Tsakali Efstathia Tsakali Jan F. M. Van Impe Dmytro Kozak Ahmed A. Abd El-Maksoud Muhammad Azeem Ashraf Tarek Gamal Abedelmaksoud |
| author_facet | Farhang Hameed Awlqadr Sobia Noreen Sobia Noreen Ammar B. Altemimi Ammar B. Altemimi Othman Abdulrahman Mohammed Syamand Ahmed Qadir Dyari H. Ahmed Zina T. Alkanan Efstathia Tsakali Efstathia Tsakali Jan F. M. Van Impe Dmytro Kozak Ahmed A. Abd El-Maksoud Muhammad Azeem Ashraf Tarek Gamal Abedelmaksoud |
| author_sort | Farhang Hameed Awlqadr |
| collection | DOAJ |
| description | This comprehensive review explores nanobubbles (NBs) technology advancements for improving drug and nutraceutical delivery and promoting human health. NBs are gas-filled nanocarriers owing to unique structures, excellent stability, flexibility, biocompatibility, and precise targeting abilities that stand out as promising drug delivery systems that improve bioavailability and enable controlled drug release. NBs demonstrate various applications, such as cancer therapy and cardiovascular health treatment, addressing neurodegenerative disorders, and aiding nutrient absorption. A significant advantage of NBs is their ultrasound-triggered cavitation, which enables targeted delivery with minimal systemic toxicity. In nutraceuticals, NBs enhance the absorption of vital nutrients, primarily those with poor bioavailability, by stabilizing and effectively targeting these compounds in the gastrointestinal system. However, long-term safety issues demand thorough preclinical studies, including bioaccumulation and cytotoxicity. The review examines important ethical, safety, and regulatory factors which must be addressed to advance NB technology in clinical and nutritional applications. The potential of these systems exists, but scalability and sustainability pose significant challenges. The full potential of nanocarriers in healthcare and nutrition depends on ongoing research into biodegradable materials and scalable production alongside the development of eco-friendly nanocarrier systems. Research results show NBs are fundamental to precision medicine and personalized nutrition, establishing a base for innovative drug and nutraceutical delivery systems. |
| format | Article |
| id | doaj-art-11d7109951574b669c6fb51f4f7ab2c7 |
| institution | Kabale University |
| issn | 2673-3013 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nanotechnology |
| spelling | doaj-art-11d7109951574b669c6fb51f4f7ab2c72025-08-20T03:50:21ZengFrontiers Media S.A.Frontiers in Nanotechnology2673-30132025-06-01710.3389/fnano.2025.15485931548593Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainabilityFarhang Hameed Awlqadr0Sobia Noreen1Sobia Noreen2Ammar B. Altemimi3Ammar B. Altemimi4Othman Abdulrahman Mohammed5Syamand Ahmed Qadir6Dyari H. Ahmed7Zina T. Alkanan8Efstathia Tsakali9Efstathia Tsakali10Jan F. M. Van Impe11Dmytro Kozak12Ahmed A. Abd El-Maksoud13Muhammad Azeem Ashraf14Tarek Gamal Abedelmaksoud15Food Science and Quality Control, Halabja Technical College, Sulaimani Polytechnic University, Sulaymaniyah, IraqDepartment of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, AustriaDepartment of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, PakistanFood Science Department, College of Agriculture, University of Basrah, Basrah, IraqCollege of Medicine, University of Warith Al-Anbiyaa, Karbala, IraqMedical Laboratory Science Department, Halabja Technical College, Sulaimani Polytechnic University, Sulaymaniya, IraqMedical Laboratory Techniques Department, Halabja Technical Institute, Research Center, Sulaimani Polytechnic University, Sulaymaniyah, IraqNursing Department, Halabja Technical Institute, Sulaimani Polytechnic University, Sulaimani, IraqFood Science Department, College of Agriculture, University of Basrah, Basrah, IraqDepartment of Food Science and Technology, University of West Attica, Egaleo, Greece0Department of Chemical Engineering, BioTeC+ Chemical and Biochemical Process, KU Leuven, Gent, Belgium0Department of Chemical Engineering, BioTeC+ Chemical and Biochemical Process, KU Leuven, Gent, Belgium0Department of Chemical Engineering, BioTeC+ Chemical and Biochemical Process, KU Leuven, Gent, Belgium1Dairy Science Department, Faculty of Agriculture, Cairo University, Giza, Egypt2Department of Supply Chain, University of Management and Technology, Lahore, Pakistan3Food Science Department, Faculty of Agriculture, Cairo University, Giza, EgyptThis comprehensive review explores nanobubbles (NBs) technology advancements for improving drug and nutraceutical delivery and promoting human health. NBs are gas-filled nanocarriers owing to unique structures, excellent stability, flexibility, biocompatibility, and precise targeting abilities that stand out as promising drug delivery systems that improve bioavailability and enable controlled drug release. NBs demonstrate various applications, such as cancer therapy and cardiovascular health treatment, addressing neurodegenerative disorders, and aiding nutrient absorption. A significant advantage of NBs is their ultrasound-triggered cavitation, which enables targeted delivery with minimal systemic toxicity. In nutraceuticals, NBs enhance the absorption of vital nutrients, primarily those with poor bioavailability, by stabilizing and effectively targeting these compounds in the gastrointestinal system. However, long-term safety issues demand thorough preclinical studies, including bioaccumulation and cytotoxicity. The review examines important ethical, safety, and regulatory factors which must be addressed to advance NB technology in clinical and nutritional applications. The potential of these systems exists, but scalability and sustainability pose significant challenges. The full potential of nanocarriers in healthcare and nutrition depends on ongoing research into biodegradable materials and scalable production alongside the development of eco-friendly nanocarrier systems. Research results show NBs are fundamental to precision medicine and personalized nutrition, establishing a base for innovative drug and nutraceutical delivery systems.https://www.frontiersin.org/articles/10.3389/fnano.2025.1548593/fullnanobubbles (NBs)drug deliverynutraceutical deliveryneurodegenerative diseasesustainability |
| spellingShingle | Farhang Hameed Awlqadr Sobia Noreen Sobia Noreen Ammar B. Altemimi Ammar B. Altemimi Othman Abdulrahman Mohammed Syamand Ahmed Qadir Dyari H. Ahmed Zina T. Alkanan Efstathia Tsakali Efstathia Tsakali Jan F. M. Van Impe Dmytro Kozak Ahmed A. Abd El-Maksoud Muhammad Azeem Ashraf Tarek Gamal Abedelmaksoud Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability Frontiers in Nanotechnology nanobubbles (NBs) drug delivery nutraceutical delivery neurodegenerative disease sustainability |
| title | Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability |
| title_full | Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability |
| title_fullStr | Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability |
| title_full_unstemmed | Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability |
| title_short | Advancement in nanobubble technology: enhancing drug and nutraceutical delivery with focus on bioavailability, targeted therapy, safety, and sustainability |
| title_sort | advancement in nanobubble technology enhancing drug and nutraceutical delivery with focus on bioavailability targeted therapy safety and sustainability |
| topic | nanobubbles (NBs) drug delivery nutraceutical delivery neurodegenerative disease sustainability |
| url | https://www.frontiersin.org/articles/10.3389/fnano.2025.1548593/full |
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