The molecular characteristics of DNA damage and repair related to P53 mutation for predicting the recurrence and immunotherapy response in hepatocellular carcinoma

The molecular characteristics of DNA damage and repair related to P53 mutation for predicting the recurrence and immunotherapy response in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths globally, owing to its high recurrence rate of 50 to 70% within five years. Despite known associations of certain DNA damage and repair (DDR) genes with tumor recurrence and drug resistance, a comprehensive...

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Bibliographic Details
Main Authors: Jiayao Ma, Diya Tang, Guangzu Cui, Xiangyang Zhang, Xinwen Wang, Yin Li, Erya Hu, Xin Zhou, Haicong Liu, Qingping Peng, Changjing Cai, Xiangying Deng, Shan Zeng, Yihong Chen, Zemin Xiao
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
P53 mutation
DNA damage and repair
HCC recurrence
Prognostic model
Immunotherapy
Online Access:https://doi.org/10.1038/s41598-025-99853-5
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