Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma
Background Olfactory groove schwannomas (OGS) are rare anterior cranial fossa base tumors with only 41 cases reported in literature. Olfactory ensheathing cell schwannoma (OECS) has similar clinico-radiological features as OGS, but a different cell of origin. In recent years, there is growing intere...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2014-05-01
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| Series: | Indian Journal of Neurosurgery |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/2277-9167.138913 |
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| author | Andi Sadayandi Ramesh Jagath Lal Gangadharan Anita Mahadevan Aravinda Hanumanthapura Ramalingaiah Bhagavatula Indira Devi |
| author_facet | Andi Sadayandi Ramesh Jagath Lal Gangadharan Anita Mahadevan Aravinda Hanumanthapura Ramalingaiah Bhagavatula Indira Devi |
| author_sort | Andi Sadayandi Ramesh |
| collection | DOAJ |
| description | Background
Olfactory groove schwannomas (OGS) are rare anterior cranial fossa base tumors with only 41 cases reported in literature. Olfactory ensheathing cell schwannoma (OECS) has similar clinico-radiological features as OGS, but a different cell of origin. In recent years, there is growing interest in OECS as more cases are being reported.
Aims
The objective was to study the clinico-radiological features of OGS and define the histological differentiation from OECS.
Materials and Methods
We retrospectively analyzed clinical, radiological, surgical and histopathological picture of all cases of OGS managed in our institute. Immuno histochemical studies were performed in these tumors for differentiating from OECS. A comprehensive review of articles published until date describing the operative treatment was done.
Results
All three cases had presented with seizures, two had anosmia and papilledema. Gross-total resection was achieved in all our patients. One patient expired in the postoperative period due to septicemia. Positive expression to newer immuno histochemical biomarker CD57 (Leu7), with negative staining to smooth muscle α-actin (SMA) was helpful in confirming the diagnosis of OGS and differentiating it from OECS in all our cases.
Conclusions
OECS, though rare has to be differentiated from OGS using immuno histochemistry. Gross-total resection of OGS with preservation of olfactory function is often possible and curative. Although these tumors are commonly treated with microsurgical skull base approaches, an endoscopic endonasal approach can be considered in some cases, with repair using mucoperiosteal pedicled flap to prevent cerebrospinal fluid leak. |
| format | Article |
| id | doaj-art-11d37a61f1db4432aec262e287c5f407 |
| institution | Kabale University |
| issn | 2277-954X 2277-9167 |
| language | English |
| publishDate | 2014-05-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Neurosurgery |
| spelling | doaj-art-11d37a61f1db4432aec262e287c5f4072025-08-20T03:54:11ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Neurosurgery2277-954X2277-91672014-05-01030208609210.4103/2277-9167.138913Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannomaAndi Sadayandi RameshJagath Lal Gangadharan0Anita Mahadevan1Aravinda Hanumanthapura Ramalingaiah2Bhagavatula Indira Devi3Departments of Neurosurgery, National Institute of Mental Health and NeurosciencesNeuropathology, National Institute of Mental Health and NeurosciencesNeuroimaging and Interventional Radiology, National Institute of Mental Health and NeurosciencesDepartments of Neurosurgery, National Institute of Mental Health and NeurosciencesBackground Olfactory groove schwannomas (OGS) are rare anterior cranial fossa base tumors with only 41 cases reported in literature. Olfactory ensheathing cell schwannoma (OECS) has similar clinico-radiological features as OGS, but a different cell of origin. In recent years, there is growing interest in OECS as more cases are being reported. Aims The objective was to study the clinico-radiological features of OGS and define the histological differentiation from OECS. Materials and Methods We retrospectively analyzed clinical, radiological, surgical and histopathological picture of all cases of OGS managed in our institute. Immuno histochemical studies were performed in these tumors for differentiating from OECS. A comprehensive review of articles published until date describing the operative treatment was done. Results All three cases had presented with seizures, two had anosmia and papilledema. Gross-total resection was achieved in all our patients. One patient expired in the postoperative period due to septicemia. Positive expression to newer immuno histochemical biomarker CD57 (Leu7), with negative staining to smooth muscle α-actin (SMA) was helpful in confirming the diagnosis of OGS and differentiating it from OECS in all our cases. Conclusions OECS, though rare has to be differentiated from OGS using immuno histochemistry. Gross-total resection of OGS with preservation of olfactory function is often possible and curative. Although these tumors are commonly treated with microsurgical skull base approaches, an endoscopic endonasal approach can be considered in some cases, with repair using mucoperiosteal pedicled flap to prevent cerebrospinal fluid leak.http://www.thieme-connect.de/DOI/DOI?10.4103/2277-9167.138913leu7 (cd57)olfactory ensheathing cell schwannomaolfactory groove schwannomaolfactory tractsmooth muscle α-actin |
| spellingShingle | Andi Sadayandi Ramesh Jagath Lal Gangadharan Anita Mahadevan Aravinda Hanumanthapura Ramalingaiah Bhagavatula Indira Devi Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma Indian Journal of Neurosurgery leu7 (cd57) olfactory ensheathing cell schwannoma olfactory groove schwannoma olfactory tract smooth muscle α-actin |
| title | Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma |
| title_full | Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma |
| title_fullStr | Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma |
| title_full_unstemmed | Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma |
| title_short | Clinical, radiological, surgical, and pathological determinants of olfactory groove schwannoma |
| title_sort | clinical radiological surgical and pathological determinants of olfactory groove schwannoma |
| topic | leu7 (cd57) olfactory ensheathing cell schwannoma olfactory groove schwannoma olfactory tract smooth muscle α-actin |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/2277-9167.138913 |
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