Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited treatment options at advanced stages. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, plays a pivotal role in regulating immune responses through the gut...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2486519 |
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| _version_ | 1850048941327908864 |
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| author | Mingyao Huang Quansong Ji Huiyan Huang Xiaoqian Wang Lin Wang |
| author_facet | Mingyao Huang Quansong Ji Huiyan Huang Xiaoqian Wang Lin Wang |
| author_sort | Mingyao Huang |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited treatment options at advanced stages. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, plays a pivotal role in regulating immune responses through the gut-liver axis. Emerging evidence underscores its impact on HCC progression and the efficacy of immunotherapy. This review explores the intricate interactions between gut microbiota and the immune system in HCC, with a focus on key immune cells and pathways involved in tumor immunity. Additionally, it highlights strategies for modulating the gut microbiota – such as fecal microbiota transplantation, dietary interventions, and probiotics – as potential approaches to enhancing immunotherapy outcomes. A deeper understanding of these mechanisms could pave the way for novel therapeutic strategies aimed at improving patient prognosis. |
| format | Article |
| id | doaj-art-11d2d7eadb0f4c0bbc13bcfa355fb2ff |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-11d2d7eadb0f4c0bbc13bcfa355fb2ff2025-08-20T02:53:50ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2486519Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modificationMingyao Huang0Quansong Ji1Huiyan Huang2Xiaoqian Wang3Lin Wang4School of Basic Medicine, Putian University, Putian, Fujian, ChinaDepartment of Urology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaWard 3, De’an Hospital, Xianyou County, Putian, Fujian, ChinaDepartment of Rehabilitation Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, ChinaDepartment of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, ChinaHepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited treatment options at advanced stages. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, plays a pivotal role in regulating immune responses through the gut-liver axis. Emerging evidence underscores its impact on HCC progression and the efficacy of immunotherapy. This review explores the intricate interactions between gut microbiota and the immune system in HCC, with a focus on key immune cells and pathways involved in tumor immunity. Additionally, it highlights strategies for modulating the gut microbiota – such as fecal microbiota transplantation, dietary interventions, and probiotics – as potential approaches to enhancing immunotherapy outcomes. A deeper understanding of these mechanisms could pave the way for novel therapeutic strategies aimed at improving patient prognosis.https://www.tandfonline.com/doi/10.1080/19490976.2025.2486519Gut microbiotaHCCimmune regulationimmunotherapygut-liver axis |
| spellingShingle | Mingyao Huang Quansong Ji Huiyan Huang Xiaoqian Wang Lin Wang Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification Gut Microbes Gut microbiota HCC immune regulation immunotherapy gut-liver axis |
| title | Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification |
| title_full | Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification |
| title_fullStr | Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification |
| title_full_unstemmed | Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification |
| title_short | Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification |
| title_sort | gut microbiota in hepatocellular carcinoma immunotherapy immune microenvironment remodeling and gut microbiota modification |
| topic | Gut microbiota HCC immune regulation immunotherapy gut-liver axis |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2486519 |
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