Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data

Recent advances in systemic therapy for advanced biliary tract cancer: A systematic review and meta-analysis using reconstructed RCT survival data

Background & Aims: Gemcitabine/cisplatin (GemCis) was the long-standing first-line treatment for advanced biliary tract cancers (BTCs). Following positive results from the TOPAZ-01 and KEYNOTE-966 trials, immune checkpoint inhibitors (ICIs) combined with chemotherapy are now the standard of...

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Bibliographic Details
Main Authors: Zhihao Li, Daniel Aliseda, Owen Jones, Luckshi Rajendran, Christian Magyar, Robert Grant, Grainne M. O’Kane, Anna Saborowski, Gonzalo Sapisochin, Arndt Vogel
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:JHEP Reports
Subjects:
Biliary tract cancers
Cholangiocarcinoma
Systemic therapy
First-line therapy
Immunotherapy
Systematic review
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924002945
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