Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial

Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial

Abstract Background Convalescent plasma (CP) reduced the mortality in COVID-19 induced ARDS (C-ARDS) patients treated in the CONFIDENT trial. As patients are immunologically heterogeneous, we hypothesized that clusters may differ in their treatment responses to CP. Methods We measured 20 cytokines,...

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Main Authors: Benoît Misset, Anh Nguyet Diep, Axelle Bertrand, Michael Piagnerelli, Eric Hoste, Isabelle Michaux, Elisabeth De Waele, Alexander Dumoulin, Philippe G. Jorens, Emmanuel van der Hauwaert, Frédéric Vallot, Walter Swinnen, Nicolas De Schryver, Nathalie de Mey, Nathalie Layios, Jean-Baptiste Mesland, Sébastien Robinet, Etienne Cavalier, Anne-Françoise Donneau, Michel Moutschen, Pierre-François Laterre
Format: Article
Language:English
Published: SpringerOpen 2024-10-01
Series:Annals of Intensive Care
Subjects:
COVID-19
Convalescent plasma
ARDS
Immune response
Phenotypes
Online Access:https://doi.org/10.1186/s13613-024-01392-1
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