Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene
Many mammalian genes are clustered on the genomes, and hence the genes in the same cluster can be regulated through a common regulatory element. We indeed showed previously that the perilipin/PEX11α gene pair is transactivated tissue-selectively by PPARγ and PPARα, respectively, through a common bi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/PPAR/2006/71916 |
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| author | Mst. Hasina Akter Md. Abdur Razzaque Liu Yang Toshio Fumoto Kiyoto Motojima Tomohiro Yamaguchi Fumiko Hirose Takashi Osumi |
| author_facet | Mst. Hasina Akter Md. Abdur Razzaque Liu Yang Toshio Fumoto Kiyoto Motojima Tomohiro Yamaguchi Fumiko Hirose Takashi Osumi |
| author_sort | Mst. Hasina Akter |
| collection | DOAJ |
| description | Many mammalian genes are clustered on the genomes, and hence the genes in the same cluster can be regulated through a common regulatory element. We indeed showed previously that the perilipin/PEX11α gene pair is transactivated tissue-selectively by PPARγ and PPARα, respectively, through a common binding site. In the present study, we identified a gene, named GSPA, neighboring a canonical PPAR target, acyl-CoA oxidase (AOX) gene. GSPA expression was induced by a peroxisome proliferator, Wy14,643, in the liver of wild-type mice, but not PPARα-null mice. GSPA and AOX share the promoter and two peroxisome proliferator-response elements. GSPA mRNA was also found in the heart and skeletal muscle, as well as 3T3-L1 cells. GSPA encodes a protein of 161 amino acids that is enriched in 3T3-L1 cells. Even other gene pairs might be regulated through common sequence elements, and conversely it would be interesting how each gene is aptly regulated in clusters. |
| format | Article |
| id | doaj-art-11bef3e6615e484383af08f35d877a6c |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-11bef3e6615e484383af08f35d877a6c2025-02-03T07:24:32ZengWileyPPAR Research1687-47571687-47652006-01-01200610.1155/PPAR/2006/7191671916Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase GeneMst. Hasina Akter0Md. Abdur Razzaque1Liu Yang2Toshio Fumoto3Kiyoto Motojima4Tomohiro Yamaguchi5Fumiko Hirose6Takashi Osumi7Graduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, JapanInternational Research and Educational Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo, Shinjuku 162-8666, JapanGraduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, JapanGraduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, JapanDepartment of Biochemistry, Meiji Pharmaceutical University, Tokyo, Kiyose 204-8588, JapanGraduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, JapanGraduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, JapanGraduate School of Life Science, University of Hyogo, Hyogo, Kamigori 678-1297, JapanMany mammalian genes are clustered on the genomes, and hence the genes in the same cluster can be regulated through a common regulatory element. We indeed showed previously that the perilipin/PEX11α gene pair is transactivated tissue-selectively by PPARγ and PPARα, respectively, through a common binding site. In the present study, we identified a gene, named GSPA, neighboring a canonical PPAR target, acyl-CoA oxidase (AOX) gene. GSPA expression was induced by a peroxisome proliferator, Wy14,643, in the liver of wild-type mice, but not PPARα-null mice. GSPA and AOX share the promoter and two peroxisome proliferator-response elements. GSPA mRNA was also found in the heart and skeletal muscle, as well as 3T3-L1 cells. GSPA encodes a protein of 161 amino acids that is enriched in 3T3-L1 cells. Even other gene pairs might be regulated through common sequence elements, and conversely it would be interesting how each gene is aptly regulated in clusters.http://dx.doi.org/10.1155/PPAR/2006/71916 |
| spellingShingle | Mst. Hasina Akter Md. Abdur Razzaque Liu Yang Toshio Fumoto Kiyoto Motojima Tomohiro Yamaguchi Fumiko Hirose Takashi Osumi Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene PPAR Research |
| title | Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene |
| title_full | Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene |
| title_fullStr | Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene |
| title_full_unstemmed | Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene |
| title_short | Identification of a Gene Sharing a Promoter and Peroxisome Proliferator-Response Elements With Acyl-CoA Oxidase Gene |
| title_sort | identification of a gene sharing a promoter and peroxisome proliferator response elements with acyl coa oxidase gene |
| url | http://dx.doi.org/10.1155/PPAR/2006/71916 |
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