Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021
The relationship between air pollution exposure and non-allergic rhinitis (NAR) risk in children is underexplored and uncertain. Therefore, the impact of numerous air pollutants on the incidence of NAR in a Chinese pediatric population were investigated. Data on daily outpatient visits for NAR among...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132401666X |
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| author | Wei Cui Hongxia Gao Liran Zhu Yuanyuan Xu Haipeng Liu |
| author_facet | Wei Cui Hongxia Gao Liran Zhu Yuanyuan Xu Haipeng Liu |
| author_sort | Wei Cui |
| collection | DOAJ |
| description | The relationship between air pollution exposure and non-allergic rhinitis (NAR) risk in children is underexplored and uncertain. Therefore, the impact of numerous air pollutants on the incidence of NAR in a Chinese pediatric population were investigated. Data on daily outpatient visits for NAR among children aged 0–18 years from 2015 to 2021 were obtained from Anhui Provincial Children’s Hospital. A quasi-Poisson generalized linear regression model combined with a distributed lag nonlinear model was applied to evaluate the association between air pollution and outpatient visits for childhood NAR. A total of 38233 NAR outpatients were included and a positive association and cumulative effects between air pollution and childhood NAR were observed. The relative risks (RRs) and 95 % confidence intervals (95 % CIs) for childhood NAR at the 75th percentile of NO2, SO2, PM10, PM2.5, O3, and CO against their minimum concentrations were 1.157 (95 % CI: 1.089, 1.23), 1.078 (1.005, 1.157), 1.168 (1.089, 1.252), 1.076 (1.02, 1.136), 1.033 (0.961, 1.11) and 1.07 (1.01, 1.134), respectively. The cumulative effects of the air pollutants were pronounced, which was much higher than each single effects. Furthermore, the risk estimates for childhood NAR during the cold season were higher than those in the warm season. Lastly, boys and school children were found to be more vulnerable to air pollutants than girls and preschool children. All these findings suggest that air pollutants have adverse effects on childhood NAR, even at levels below those recommended by the air quality guidelines. Our study results highlight the significance of paying attention to the effects of air pollutants to prevent NAR occurrence, particularly in boys and school children and during the cold season. Therefore, stronger control measures to mitigate air pollution must be implemented to decrease NAR incidence in the pediatric population. |
| format | Article |
| id | doaj-art-11bec6228e0a48ff9ed4695be3e72a66 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-11bec6228e0a48ff9ed4695be3e72a662025-02-12T05:29:55ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117590Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021Wei Cui0Hongxia Gao1Liran Zhu2Yuanyuan Xu3Haipeng Liu4Department of Scientific Research, Anhui Provincial Children's Hospital (Anhui Hospital, Children’s Hospital of Fudan University), Hefei, Anhui 230051,China; Anhui Institute of Pediatric Research, Hefei, Anhui 230051, China; Children's Medical Center of Anhui Medical University, Hefei, Anhui 230032, ChinaDepartment of Gynecology and Obstetric, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230000, ChinaDepartment of Scientific Research, Anhui Provincial Children's Hospital (Anhui Hospital, Children’s Hospital of Fudan University), Hefei, Anhui 230051,China; Anhui Institute of Pediatric Research, Hefei, Anhui 230051, China; Children's Medical Center of Anhui Medical University, Hefei, Anhui 230032, ChinaChildren's Medical Center of Anhui Medical University, Hefei, Anhui 230032, China; Pediatric Intensive Care Unit, Anhui Provincial Children's Hospital (Anhui Hospital of Children’s Hospital of Fudan University), Hefei, Anhui 230051, ChinaDepartment of Scientific Research, Anhui Provincial Children's Hospital (Anhui Hospital, Children’s Hospital of Fudan University), Hefei, Anhui 230051,China; Anhui Institute of Pediatric Research, Hefei, Anhui 230051, China; Children's Medical Center of Anhui Medical University, Hefei, Anhui 230032, China; Corresponding author at: Department of Scientific Research, Anhui Provincial Children's Hospital (Anhui Hospital, Children’s Hospital of Fudan University), Hefei, Anhui 230051, China.The relationship between air pollution exposure and non-allergic rhinitis (NAR) risk in children is underexplored and uncertain. Therefore, the impact of numerous air pollutants on the incidence of NAR in a Chinese pediatric population were investigated. Data on daily outpatient visits for NAR among children aged 0–18 years from 2015 to 2021 were obtained from Anhui Provincial Children’s Hospital. A quasi-Poisson generalized linear regression model combined with a distributed lag nonlinear model was applied to evaluate the association between air pollution and outpatient visits for childhood NAR. A total of 38233 NAR outpatients were included and a positive association and cumulative effects between air pollution and childhood NAR were observed. The relative risks (RRs) and 95 % confidence intervals (95 % CIs) for childhood NAR at the 75th percentile of NO2, SO2, PM10, PM2.5, O3, and CO against their minimum concentrations were 1.157 (95 % CI: 1.089, 1.23), 1.078 (1.005, 1.157), 1.168 (1.089, 1.252), 1.076 (1.02, 1.136), 1.033 (0.961, 1.11) and 1.07 (1.01, 1.134), respectively. The cumulative effects of the air pollutants were pronounced, which was much higher than each single effects. Furthermore, the risk estimates for childhood NAR during the cold season were higher than those in the warm season. Lastly, boys and school children were found to be more vulnerable to air pollutants than girls and preschool children. All these findings suggest that air pollutants have adverse effects on childhood NAR, even at levels below those recommended by the air quality guidelines. Our study results highlight the significance of paying attention to the effects of air pollutants to prevent NAR occurrence, particularly in boys and school children and during the cold season. Therefore, stronger control measures to mitigate air pollution must be implemented to decrease NAR incidence in the pediatric population.http://www.sciencedirect.com/science/article/pii/S014765132401666XNon-allergic rhinitisAir pollutionCumulative effectCold season |
| spellingShingle | Wei Cui Hongxia Gao Liran Zhu Yuanyuan Xu Haipeng Liu Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021 Ecotoxicology and Environmental Safety Non-allergic rhinitis Air pollution Cumulative effect Cold season |
| title | Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021 |
| title_full | Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021 |
| title_fullStr | Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021 |
| title_full_unstemmed | Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021 |
| title_short | Short-term association between ambient air pollution and childhood non-allergic rhinitis: A time-series study at a National Children's Regional Medical Center, in Hefei, China, from 2015 to 2021 |
| title_sort | short term association between ambient air pollution and childhood non allergic rhinitis a time series study at a national children s regional medical center in hefei china from 2015 to 2021 |
| topic | Non-allergic rhinitis Air pollution Cumulative effect Cold season |
| url | http://www.sciencedirect.com/science/article/pii/S014765132401666X |
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