Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity
Ageing is a progressive functional decline in health conditions and a risk factor for many chronic diseases. To address the elevated burden of age-related pathologies, the ageing process has been extensively studied over the past decades, and yet the underlying mechanisms remain to be fully understo...
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IMR Press
2025-07-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/30/7/10.31083/FBL42709 |
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| author | Afsar U. Ahmed |
| author_facet | Afsar U. Ahmed |
| author_sort | Afsar U. Ahmed |
| collection | DOAJ |
| description | Ageing is a progressive functional decline in health conditions and a risk factor for many chronic diseases. To address the elevated burden of age-related pathologies, the ageing process has been extensively studied over the past decades, and yet the underlying mechanisms remain to be fully understood. One of the prominent features of ageing is cellular senescence, a special form of durable cell-cycle arrest. While senescent cells release the senescence-associated secretory phenotype (SASP) molecules that recruit immune cells to facilitate the clearance of senescent cells, senescence is also indispensable for many essential physiological functions. However, a ‘chronic’ nature of senescence arises due to immune deficiencies and persists during ageing. Immunosenescence, the ageing of immune cells, is the underlying key driving the pathological burdens of senescence, leading to systemic ageing as demonstrated by animal studies. Thymic regeneration has been shown by several studies to be a potential anti-ageing intervention, restoring immunity as well as reversing immunosenescence and ageing. The specific targeting of senescent cells by senolytic and/or senomorphic drugs is also promising but needs to be dealt with caution to protect the essential physiological roles of senescence. A deeper understanding of the biological origins of immunosenescence is crucial for unveiling the potential root cause of ageing. |
| format | Article |
| id | doaj-art-11be727465e2425ca8bc0d4f6e54607c |
| institution | DOAJ |
| issn | 2768-6701 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-11be727465e2425ca8bc0d4f6e54607c2025-08-20T02:56:26ZengIMR PressFrontiers in Bioscience-Landmark2768-67012025-07-013074270910.31083/FBL42709S2768-6701(25)01769-1Immunosenescence and Ageing: An Entangled Web of Senescence and Declining ImmunityAfsar U. Ahmed0Department of Microbiology, Anatomy, Physiology and Pharmacology (MAPP), School of Agriculture, Biomedicine and Environment (SABE), La Trobe University, Melbourne, VIC 3086, AustraliaAgeing is a progressive functional decline in health conditions and a risk factor for many chronic diseases. To address the elevated burden of age-related pathologies, the ageing process has been extensively studied over the past decades, and yet the underlying mechanisms remain to be fully understood. One of the prominent features of ageing is cellular senescence, a special form of durable cell-cycle arrest. While senescent cells release the senescence-associated secretory phenotype (SASP) molecules that recruit immune cells to facilitate the clearance of senescent cells, senescence is also indispensable for many essential physiological functions. However, a ‘chronic’ nature of senescence arises due to immune deficiencies and persists during ageing. Immunosenescence, the ageing of immune cells, is the underlying key driving the pathological burdens of senescence, leading to systemic ageing as demonstrated by animal studies. Thymic regeneration has been shown by several studies to be a potential anti-ageing intervention, restoring immunity as well as reversing immunosenescence and ageing. The specific targeting of senescent cells by senolytic and/or senomorphic drugs is also promising but needs to be dealt with caution to protect the essential physiological roles of senescence. A deeper understanding of the biological origins of immunosenescence is crucial for unveiling the potential root cause of ageing.https://www.imrpress.com/journal/FBL/30/7/10.31083/FBL42709ageingimmunitysenescenceimmunosenescencesenescence-associated secretory phenotype (sasp)inflammationsenolytic drugssenomorphic drugs |
| spellingShingle | Afsar U. Ahmed Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity Frontiers in Bioscience-Landmark ageing immunity senescence immunosenescence senescence-associated secretory phenotype (sasp) inflammation senolytic drugs senomorphic drugs |
| title | Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity |
| title_full | Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity |
| title_fullStr | Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity |
| title_full_unstemmed | Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity |
| title_short | Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity |
| title_sort | immunosenescence and ageing an entangled web of senescence and declining immunity |
| topic | ageing immunity senescence immunosenescence senescence-associated secretory phenotype (sasp) inflammation senolytic drugs senomorphic drugs |
| url | https://www.imrpress.com/journal/FBL/30/7/10.31083/FBL42709 |
| work_keys_str_mv | AT afsaruahmed immunosenescenceandageinganentangledwebofsenescenceanddecliningimmunity |