Visceral childhood leishmaniasis in southern Turkey: experience of twenty years
One hundred and one children with visceral leishmaniasis (VL) who admitted to Akdeniz University Hospital during a 20-year period were analyzed. Median age of the patients was 3 years (range: 5.5 months-13 years). The most common symptoms at presentation were fever, pallor and abdominal diste...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2009-02-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2248 |
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| author | Oğuz Dursun Seyhan Erişir Akif Yeşilipek |
| author_facet | Oğuz Dursun Seyhan Erişir Akif Yeşilipek |
| author_sort | Oğuz Dursun |
| collection | DOAJ |
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One hundred and one children with visceral leishmaniasis (VL) who admitted to Akdeniz University Hospital during a 20-year period were analyzed. Median age of the patients was 3 years (range: 5.5 months-13 years). The most common symptoms at presentation were fever, pallor and abdominal distension. Splenomegaly was found in all of the patients while hepatomegaly was present in 98%. Anemia (96%), leukopenia (74%) and thrombocytopenia (56%) were the main laboratory abnormalities. Thirty-three (33%) of the patients were pancytopenic on admission. Bone marrow smear was positive for leishmania in 91% of the patients. Seventy-four patients were treated with antimony +/- pentamidine and 27 with amphotericin B. Three of our patients died because of secondary infections and hemorrhage. Relapse was observed in two patients. No patient showed post kala-azar dermal leishmaniasis findings. We conclude that VL should be considered in patients with prolonged fever, hepatosplenomegaly and cytopenia who live in an endemic region. Amphotericin B is a therapeutic agent as effective as pentavalent antimony compounds and could be preferred.
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| format | Article |
| id | doaj-art-11bdc080935f47c2bd04cbbc4ef5226d |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2009-02-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-11bdc080935f47c2bd04cbbc4ef5226d2025-08-20T02:01:49ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212009-02-01511Visceral childhood leishmaniasis in southern Turkey: experience of twenty yearsOğuz Dursun0Seyhan ErişirAkif YeşilipekDivision of Intensive Care, Department of Pediatrics, Akdeniz University Faculty of Medicine, Antalya, Turkey. One hundred and one children with visceral leishmaniasis (VL) who admitted to Akdeniz University Hospital during a 20-year period were analyzed. Median age of the patients was 3 years (range: 5.5 months-13 years). The most common symptoms at presentation were fever, pallor and abdominal distension. Splenomegaly was found in all of the patients while hepatomegaly was present in 98%. Anemia (96%), leukopenia (74%) and thrombocytopenia (56%) were the main laboratory abnormalities. Thirty-three (33%) of the patients were pancytopenic on admission. Bone marrow smear was positive for leishmania in 91% of the patients. Seventy-four patients were treated with antimony +/- pentamidine and 27 with amphotericin B. Three of our patients died because of secondary infections and hemorrhage. Relapse was observed in two patients. No patient showed post kala-azar dermal leishmaniasis findings. We conclude that VL should be considered in patients with prolonged fever, hepatosplenomegaly and cytopenia who live in an endemic region. Amphotericin B is a therapeutic agent as effective as pentavalent antimony compounds and could be preferred. https://turkjpediatr.org/article/view/2248 |
| spellingShingle | Oğuz Dursun Seyhan Erişir Akif Yeşilipek Visceral childhood leishmaniasis in southern Turkey: experience of twenty years The Turkish Journal of Pediatrics |
| title | Visceral childhood leishmaniasis in southern Turkey: experience of twenty years |
| title_full | Visceral childhood leishmaniasis in southern Turkey: experience of twenty years |
| title_fullStr | Visceral childhood leishmaniasis in southern Turkey: experience of twenty years |
| title_full_unstemmed | Visceral childhood leishmaniasis in southern Turkey: experience of twenty years |
| title_short | Visceral childhood leishmaniasis in southern Turkey: experience of twenty years |
| title_sort | visceral childhood leishmaniasis in southern turkey experience of twenty years |
| url | https://turkjpediatr.org/article/view/2248 |
| work_keys_str_mv | AT oguzdursun visceralchildhoodleishmaniasisinsouthernturkeyexperienceoftwentyyears AT seyhanerisir visceralchildhoodleishmaniasisinsouthernturkeyexperienceoftwentyyears AT akifyesilipek visceralchildhoodleishmaniasisinsouthernturkeyexperienceoftwentyyears |