Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi

Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi

Antibiotics are essential for the treatment of typhoid fever, which is caused by Salmonella Typhi. The global increase of antibiotic resistance in S. Typhi is a significant public health threat. The traditional approach to discovering new drugs is a lengthy process. To address this, ligand-based pha...

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Bibliographic Details
Main Authors: Divyapriya Karthikeyan, Sanjit Kumar, NS Jayaprakash
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Chemical Physics Impact
Subjects:
Antimicrobial resistance
Raetz pathway
Lipid a synthesis
LpxH
Pharmacophore
MOE
Online Access:http://www.sciencedirect.com/science/article/pii/S266702242500012X
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