Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops

Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of Gαq Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops

Abstract Uveal melanoma (UM), the predominant primary ocular malignancy, often progresses to liver metastasis with limited therapeutic options. The interplay of the tumor microenvironment, encompassing secreted soluble factors, plays a crucial role in facilitating liver metastasis. In this study, th...

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Main Authors: Shumin Ouyang, Shuo Shi, Wen Ding, Yang Ge, Yingxue Su, Jianshan Mo, Keren Peng, Qiyi Zhang, Guopin Liu, Wei Xiao, Peibin Yue, Jinjian Lu, Yandong Wang, Xiaofeng Xiong, Xiaolei Zhang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
Gαq mutant
hepatic stellate cells
liver metastasis
tumor microenvironment
uveal melanoma
VGF
Online Access:https://doi.org/10.1002/advs.202407967
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