Innovative microbial strategies in atopic dermatitis
Atopic dermatitis (AD) is characterized by chronic and recurrent itching with a high burden of disability-adjusted life years (DALYs, a measure of overall disease burden). Traditional treatments mainly include corticosteroids, which have a good effect on controlling inflammation but adverse side eff...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605434/full |
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| author | Jingtai Ma Jingtai Ma Yiting Fang Yiting Fang Jinxing Hu Shiqi Li Lilian Zeng Siyi Chen Zhifeng Li Ruiling Meng Xingfen Yang Fenglin Zhang Guiyuan Ji Peihua Liao Liang Chen Wei Wu Wei Wu |
| author_facet | Jingtai Ma Jingtai Ma Yiting Fang Yiting Fang Jinxing Hu Shiqi Li Lilian Zeng Siyi Chen Zhifeng Li Ruiling Meng Xingfen Yang Fenglin Zhang Guiyuan Ji Peihua Liao Liang Chen Wei Wu Wei Wu |
| author_sort | Jingtai Ma |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is characterized by chronic and recurrent itching with a high burden of disability-adjusted life years (DALYs, a measure of overall disease burden). Traditional treatments mainly include corticosteroids, which have a good effect on controlling inflammation but adverse side effects. Recently, advancements in understanding the pathogenesis of AD have led to the emergence of a variety of novel therapeutic approaches, such as microbiome manipulation, offering renewed hope for more effective management of this condition. These strategies are particularly promising for mild-to-moderate AD, where dysbiosis and immune imbalance (e.g., Th2 skewing) are key drivers, though some approaches (e.g., fecal microbiota transplantation) are being explored for refractory cases. It has been shown that microbiome manipulation has the potential to improve disease states and regulates the balance of the inflammatory system in a variety of ways. Various approaches have been preclinically and clinically tested, including probiotics (and multiple co-applications), prebiotics, postbiotics, unmethylated CpG motifs, fecal microbiota transplantation, herbal fermentation technology with microorganisms and phage. In this review, we discuss these microbiome manipulation methods and emphasizes the potential of microbiome-based interventions to modulate Th1/Th2 balance with fewer side effects, ultimately leading to control of inflammation in AD. Further translational research in this field is needed to integrate when we apply this therapy and the capability for disease treatment and prevention. |
| format | Article |
| id | doaj-art-1199cf12081248528e4c7556fcfe1cf6 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1199cf12081248528e4c7556fcfe1cf62025-08-20T02:46:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16054341605434Innovative microbial strategies in atopic dermatitisJingtai Ma0Jingtai Ma1Yiting Fang2Yiting Fang3Jinxing Hu4Shiqi Li5Lilian Zeng6Siyi Chen7Zhifeng Li8Ruiling Meng9Xingfen Yang10Fenglin Zhang11Guiyuan Ji12Peihua Liao13Liang Chen14Wei Wu15Wei Wu16Guangzhou Chest Hospital, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangzhou Chest Hospital, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangzhou Chest Hospital, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaNational Medical Products Administration (NMPA) Key Laboratory for Safety Evaluation of Cosmetics, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, ChinaGuangzhou Institute of Microbiology Group Co., Ltd., Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaXinjiang Uighur Autonomous Region Center for Disease Control and Prevention, Uighur, ChinaGuangzhou Chest Hospital, Guangzhou, ChinaGuangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, ChinaZhuhai Center for Disease Control and Prevention, Zhuhai, ChinaAtopic dermatitis (AD) is characterized by chronic and recurrent itching with a high burden of disability-adjusted life years (DALYs, a measure of overall disease burden). Traditional treatments mainly include corticosteroids, which have a good effect on controlling inflammation but adverse side effects. Recently, advancements in understanding the pathogenesis of AD have led to the emergence of a variety of novel therapeutic approaches, such as microbiome manipulation, offering renewed hope for more effective management of this condition. These strategies are particularly promising for mild-to-moderate AD, where dysbiosis and immune imbalance (e.g., Th2 skewing) are key drivers, though some approaches (e.g., fecal microbiota transplantation) are being explored for refractory cases. It has been shown that microbiome manipulation has the potential to improve disease states and regulates the balance of the inflammatory system in a variety of ways. Various approaches have been preclinically and clinically tested, including probiotics (and multiple co-applications), prebiotics, postbiotics, unmethylated CpG motifs, fecal microbiota transplantation, herbal fermentation technology with microorganisms and phage. In this review, we discuss these microbiome manipulation methods and emphasizes the potential of microbiome-based interventions to modulate Th1/Th2 balance with fewer side effects, ultimately leading to control of inflammation in AD. Further translational research in this field is needed to integrate when we apply this therapy and the capability for disease treatment and prevention.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605434/fullatopic dermatitismicrobial strategiesfecal microbiota transplantationprobioticspostbioticsprebiotics |
| spellingShingle | Jingtai Ma Jingtai Ma Yiting Fang Yiting Fang Jinxing Hu Shiqi Li Lilian Zeng Siyi Chen Zhifeng Li Ruiling Meng Xingfen Yang Fenglin Zhang Guiyuan Ji Peihua Liao Liang Chen Wei Wu Wei Wu Innovative microbial strategies in atopic dermatitis Frontiers in Immunology atopic dermatitis microbial strategies fecal microbiota transplantation probiotics postbiotics prebiotics |
| title | Innovative microbial strategies in atopic dermatitis |
| title_full | Innovative microbial strategies in atopic dermatitis |
| title_fullStr | Innovative microbial strategies in atopic dermatitis |
| title_full_unstemmed | Innovative microbial strategies in atopic dermatitis |
| title_short | Innovative microbial strategies in atopic dermatitis |
| title_sort | innovative microbial strategies in atopic dermatitis |
| topic | atopic dermatitis microbial strategies fecal microbiota transplantation probiotics postbiotics prebiotics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1605434/full |
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