Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1
<p>The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constituti...
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| Format: | Article |
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| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/73835 |
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| Summary: | <p>The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and dexamethasone (DEX)-inducible expression of annexin I in RA FLS. DEX increased FLS annexin I protein translocation and mRNA expression. Interleukin (IL)-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> also induced annexin I translocation and mRNA but also increased intracellular protein. DEX and IL-1 had additive effects on annexin I mRNA, but DEX inhibited the inducing effect of IL-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> on cell surface annexin I. These results indicate that glucocorticoids and IL-1<mml:math alttext="$eta$"> <mml:mi>β</mml:mi> </mml:math> upregulate the synthesis and translocation of annexin I in RA FLS, but interdependent signalling pathways are involved.</p> |
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| ISSN: | 0962-9351 |