Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study
Abstract Background The Atherogenic Index of Plasma (AIP) is a novel biomarker for assessing the severity of atherosclerosis and has been shown to be closely associated with the risk of Type 2 Diabetes Mellitus (T2DM). However, no prospective cohort study has comprehensively evaluated both the immed...
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BMC
2025-02-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-025-02619-6 |
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| author | Yongbing Sun Xinbei Lin Zhi Zou Caiwen Zhao Ao Liu Jing Zhou Zhonglin Li Xiaoling Wu Shewei Dou Jiadong Zhu Tao Li Xue Lv Yong Wang Yongli Li |
| author_facet | Yongbing Sun Xinbei Lin Zhi Zou Caiwen Zhao Ao Liu Jing Zhou Zhonglin Li Xiaoling Wu Shewei Dou Jiadong Zhu Tao Li Xue Lv Yong Wang Yongli Li |
| author_sort | Yongbing Sun |
| collection | DOAJ |
| description | Abstract Background The Atherogenic Index of Plasma (AIP) is a novel biomarker for assessing the severity of atherosclerosis and has been shown to be closely associated with the risk of Type 2 Diabetes Mellitus (T2DM). However, no prospective cohort study has comprehensively evaluated both the immediate risk stratification through baseline AIP and the long-term risk assessment through multi-time point AIP trajectories in health screened adults in relation to T2DM risk. Methods This longitudinal study included data from 42,850 participants who underwent health check-ups at Henan Provincial People’s Hospital between January 2018 and August 2024. AIP was calculated as the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C). The Kaplan-Meier method was employed to analyze the incidence of T2DM across different AIP groups. A Cox model with restricted cubic splines assessed the dose-response relationship between AIP and T2DM risk, while latent class trajectory models (LCTM) evaluated the trends of AIP over multiple time points. Cox proportional hazards models were used to examine the relationship between baseline AIP quartiles, AIP trajectories, and T2DM risk. Results During an average follow-up of 47.95 months, 3,228 participants developed T2DM. Stratifying by baseline AIP quartiles revealed that higher AIP levels were associated with an increased risk of T2DM. Compared to the lowest quartile, the highest quartile had a hazard ratio (HR) of 2.10 (95% CI: 1.74, 2.53). The LCTM identified three trajectory patterns for AIP: with the low-stable group as the reference, the medium-stable and high-stable groups had HRs of 1.72 (95% CI: 1.50, 1.96) and 2.50 (95% CI: 2.06, 3.03), respectively, indicating a significantly elevated risk of T2DM (P < 0.05). Conclusion Elevated baseline AIP levels, medium stable trajectories and high stable trajectories are associated with an increased risk of T2DM in health screened adults. |
| format | Article |
| id | doaj-art-119611fff36d4206b5bb015a9476209e |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-119611fff36d4206b5bb015a9476209e2025-02-09T12:10:48ZengBMCCardiovascular Diabetology1475-28402025-02-0124111310.1186/s12933-025-02619-6Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal studyYongbing Sun0Xinbei Lin1Zhi Zou2Caiwen Zhao3Ao Liu4Jing Zhou5Zhonglin Li6Xiaoling Wu7Shewei Dou8Jiadong Zhu9Tao Li10Xue Lv11Yong Wang12Yongli Li13Department of Medical Imaging, Zhengzhou University People’s Hospital, Henan Provincial People’s HospitalDepartment of Medical Imaging, Zhengzhou University People’s Hospital, Henan Provincial People’s HospitalDepartment of Medical Imaging, Zhengzhou University People’s Hospital, Henan Provincial People’s HospitalThe Third Affiliated Hospital of Zhengzhou UniversityDepartment of Medical Imaging, Zhengzhou University People’s Hospital, Henan Provincial People’s HospitalHenan Provincial Research Center of Clinical Medicine of Nephropathy, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s HospitalDepartment of Medical Imaging, Zhengzhou University People’s Hospital, Henan Provincial People’s HospitalDepartment of Nuclear Medicine, Henan Provincial People’s HospitalDepartment of Medical Imaging, Zhengzhou University People’s Hospital, Henan Provincial People’s HospitalDepartment of Health Management, Chronic Health Management Laboratory, Henan Provincial People’s Hospital, Zhengzhou University People’s HospitalFuwaihua Central Vascular Disease HospitalHenan Provincial People’s HospitalHenan Provincial People’s HospitalDepartment of Health Management, Chronic Health Management Laboratory, Henan Provincial People’s Hospital, Zhengzhou University People’s HospitalAbstract Background The Atherogenic Index of Plasma (AIP) is a novel biomarker for assessing the severity of atherosclerosis and has been shown to be closely associated with the risk of Type 2 Diabetes Mellitus (T2DM). However, no prospective cohort study has comprehensively evaluated both the immediate risk stratification through baseline AIP and the long-term risk assessment through multi-time point AIP trajectories in health screened adults in relation to T2DM risk. Methods This longitudinal study included data from 42,850 participants who underwent health check-ups at Henan Provincial People’s Hospital between January 2018 and August 2024. AIP was calculated as the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C). The Kaplan-Meier method was employed to analyze the incidence of T2DM across different AIP groups. A Cox model with restricted cubic splines assessed the dose-response relationship between AIP and T2DM risk, while latent class trajectory models (LCTM) evaluated the trends of AIP over multiple time points. Cox proportional hazards models were used to examine the relationship between baseline AIP quartiles, AIP trajectories, and T2DM risk. Results During an average follow-up of 47.95 months, 3,228 participants developed T2DM. Stratifying by baseline AIP quartiles revealed that higher AIP levels were associated with an increased risk of T2DM. Compared to the lowest quartile, the highest quartile had a hazard ratio (HR) of 2.10 (95% CI: 1.74, 2.53). The LCTM identified three trajectory patterns for AIP: with the low-stable group as the reference, the medium-stable and high-stable groups had HRs of 1.72 (95% CI: 1.50, 1.96) and 2.50 (95% CI: 2.06, 3.03), respectively, indicating a significantly elevated risk of T2DM (P < 0.05). Conclusion Elevated baseline AIP levels, medium stable trajectories and high stable trajectories are associated with an increased risk of T2DM in health screened adults.https://doi.org/10.1186/s12933-025-02619-6Plasma atherogenic indexType 2 diabetes mellitusTrajectory analysisProspective longitudinal study |
| spellingShingle | Yongbing Sun Xinbei Lin Zhi Zou Caiwen Zhao Ao Liu Jing Zhou Zhonglin Li Xiaoling Wu Shewei Dou Jiadong Zhu Tao Li Xue Lv Yong Wang Yongli Li Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study Cardiovascular Diabetology Plasma atherogenic index Type 2 diabetes mellitus Trajectory analysis Prospective longitudinal study |
| title | Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study |
| title_full | Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study |
| title_fullStr | Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study |
| title_full_unstemmed | Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study |
| title_short | Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study |
| title_sort | baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population a large longitudinal study |
| topic | Plasma atherogenic index Type 2 diabetes mellitus Trajectory analysis Prospective longitudinal study |
| url | https://doi.org/10.1186/s12933-025-02619-6 |
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