Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016
ObjectiveThis study aims to investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and bone mineral density (BMD) in children and adolescents aged 8-19 years.MethodsA cross-sectional design was used, utilizing NHANES data from 2011-2016, including 3,205 participants age...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1537574/full |
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| author | Dejun Cun Nan Yang Lin Zhou Wenxing Zeng Bin Chen Zichen Pan Huang Feng Ziwei Jiang |
| author_facet | Dejun Cun Nan Yang Lin Zhou Wenxing Zeng Bin Chen Zichen Pan Huang Feng Ziwei Jiang |
| author_sort | Dejun Cun |
| collection | DOAJ |
| description | ObjectiveThis study aims to investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and bone mineral density (BMD) in children and adolescents aged 8-19 years.MethodsA cross-sectional design was used, utilizing NHANES data from 2011-2016, including 3,205 participants aged 8 to 19 years. Weighted multivariable regression analysis was conducted to assess the association between SIRI and BMD at the lumbar spine, pelvis, trunk, and whole body. Additionally, smooth curve fitting was applied to examine the nonlinear relationship between SIRI and BMD, and subgroup analyses were performed to explore potential interaction effects and modifiers.ResultsSIRI was significantly positively correlated with BMD at the pelvis, trunk, and whole body (p < 0.05). After adjusting for covariates, a one-unit increase in ln(SIRI) was associated with increases in BMD of 0.018 g/cm², 0.006 g/cm², and 0.005 g/cm² for the pelvis, trunk, and whole body, respectively. Nonlinear analysis revealed a saturation effect between ln(SIRI) and BMD, with a more pronounced impact at specific threshold values. Subgroup analysis indicated that gender, age, BMI and total calcium levels modulated the relationship between SIRI and BMD.ConclusionSIRI is significantly associated with BMD in children and adolescents, with a positive effect on BMD at specific threshold levels. This finding suggests that SIRI may serve as a potential biomarker for assessing the risk of low bone mineral density, offering theoretical support for the prevention and intervention of bone health issues such as osteoporosis. |
| format | Article |
| id | doaj-art-11958d4fdeb3459f89e8d834ab74f7ba |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-11958d4fdeb3459f89e8d834ab74f7ba2025-08-20T02:15:34ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15375741537574Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016Dejun Cun0Nan Yang1Lin Zhou2Wenxing Zeng3Bin Chen4Zichen Pan5Huang Feng6Ziwei Jiang7Department of Traditional Chinese Medicine, The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, The First Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, The First Clinical College of Yunnan University of Traditional Chinese Medicine, Kunming, ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaDepartment of Lower Limb Trauma Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, ChinaDepartment of Lower Limb Trauma Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, ChinaObjectiveThis study aims to investigate the relationship between the Systemic Inflammatory Response Index (SIRI) and bone mineral density (BMD) in children and adolescents aged 8-19 years.MethodsA cross-sectional design was used, utilizing NHANES data from 2011-2016, including 3,205 participants aged 8 to 19 years. Weighted multivariable regression analysis was conducted to assess the association between SIRI and BMD at the lumbar spine, pelvis, trunk, and whole body. Additionally, smooth curve fitting was applied to examine the nonlinear relationship between SIRI and BMD, and subgroup analyses were performed to explore potential interaction effects and modifiers.ResultsSIRI was significantly positively correlated with BMD at the pelvis, trunk, and whole body (p < 0.05). After adjusting for covariates, a one-unit increase in ln(SIRI) was associated with increases in BMD of 0.018 g/cm², 0.006 g/cm², and 0.005 g/cm² for the pelvis, trunk, and whole body, respectively. Nonlinear analysis revealed a saturation effect between ln(SIRI) and BMD, with a more pronounced impact at specific threshold values. Subgroup analysis indicated that gender, age, BMI and total calcium levels modulated the relationship between SIRI and BMD.ConclusionSIRI is significantly associated with BMD in children and adolescents, with a positive effect on BMD at specific threshold levels. This finding suggests that SIRI may serve as a potential biomarker for assessing the risk of low bone mineral density, offering theoretical support for the prevention and intervention of bone health issues such as osteoporosis.https://www.frontiersin.org/articles/10.3389/fendo.2025.1537574/fullsystemic inflammatory response indexbone mineral densitychildren and adolescentsNHANEScross-sectional study |
| spellingShingle | Dejun Cun Nan Yang Lin Zhou Wenxing Zeng Bin Chen Zichen Pan Huang Feng Ziwei Jiang Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016 Frontiers in Endocrinology systemic inflammatory response index bone mineral density children and adolescents NHANES cross-sectional study |
| title | Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016 |
| title_full | Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016 |
| title_fullStr | Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016 |
| title_full_unstemmed | Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016 |
| title_short | Relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8-19 years: a cross-sectional study based on NHANES 2011-2016 |
| title_sort | relationship between systemic inflammatory response index and bone mineral density in children and adolescents aged 8 19 years a cross sectional study based on nhanes 2011 2016 |
| topic | systemic inflammatory response index bone mineral density children and adolescents NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1537574/full |
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