The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment
Obesity increases the risk of cardiovascular disease, diabetes and chronic kidney disease. Obesity-related glomerulopathy (ORG) is a potentially reversible cause of kidney disease that often progresses silently until it reaches irreversible stages. However, we are still lacking a sensitive and speci...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/5/1030 |
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| author | Maruja Navarro-Díaz Marina López-Martínez |
| author_facet | Maruja Navarro-Díaz Marina López-Martínez |
| author_sort | Maruja Navarro-Díaz |
| collection | DOAJ |
| description | Obesity increases the risk of cardiovascular disease, diabetes and chronic kidney disease. Obesity-related glomerulopathy (ORG) is a potentially reversible cause of kidney disease that often progresses silently until it reaches irreversible stages. However, we are still lacking a sensitive and specific biomarker to identify patients with obesity who are at risk of developing CKD. The role of microRNAs (miRNAs) has emerged as a promising area for diagnostic and therapeutic applications in kidney disease. Recent research has highlighted the specific roles of various miRNAs in renal function, showing that their dysregulation can contribute to the development of kidney diseases. This review will discuss the emerging role of miRNAs in the context of ORG, focusing on their potential as biomarkers and therapeutic targets for this increasingly prevalent disease. |
| format | Article |
| id | doaj-art-118e3018fbbc48b290cfd80edb3685ac |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-118e3018fbbc48b290cfd80edb3685ac2025-08-20T03:14:45ZengMDPI AGBiomedicines2227-90592025-04-01135103010.3390/biomedicines13051030The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and TreatmentMaruja Navarro-Díaz0Marina López-Martínez1Genomic Platform, Germans Trias i Pujol’s Research Insitute, 08916 Badalona, SpainNephrology Department, Vall d’Hebron University Hospital, 08035 Barcelona, SpainObesity increases the risk of cardiovascular disease, diabetes and chronic kidney disease. Obesity-related glomerulopathy (ORG) is a potentially reversible cause of kidney disease that often progresses silently until it reaches irreversible stages. However, we are still lacking a sensitive and specific biomarker to identify patients with obesity who are at risk of developing CKD. The role of microRNAs (miRNAs) has emerged as a promising area for diagnostic and therapeutic applications in kidney disease. Recent research has highlighted the specific roles of various miRNAs in renal function, showing that their dysregulation can contribute to the development of kidney diseases. This review will discuss the emerging role of miRNAs in the context of ORG, focusing on their potential as biomarkers and therapeutic targets for this increasingly prevalent disease.https://www.mdpi.com/2227-9059/13/5/1030microRNAbiomarkerobesity-related glomerulopathy |
| spellingShingle | Maruja Navarro-Díaz Marina López-Martínez The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment Biomedicines microRNA biomarker obesity-related glomerulopathy |
| title | The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment |
| title_full | The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment |
| title_fullStr | The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment |
| title_full_unstemmed | The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment |
| title_short | The Role of miRNAs as Early Biomarkers in Obesity-Related Glomerulopathy: Implications for Early Detection and Treatment |
| title_sort | role of mirnas as early biomarkers in obesity related glomerulopathy implications for early detection and treatment |
| topic | microRNA biomarker obesity-related glomerulopathy |
| url | https://www.mdpi.com/2227-9059/13/5/1030 |
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