Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease
The coexistence of anxiety or depression with coronary heart disease (CHD) is a significant clinical challenge in cardiovascular medicine. Recent studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activity could be a promising focus in understanding and addressing the development...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-12-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/23/12/10.31083/j.jin2312222 |
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| author | Lan-Shuan Feng Yi-Ming Wang Huan Liu Bo Ning Hu-Bin Yu Shi-Lin Li Yu-Ting Wang Ming-Jun Zhao Jing Ma |
| author_facet | Lan-Shuan Feng Yi-Ming Wang Huan Liu Bo Ning Hu-Bin Yu Shi-Lin Li Yu-Ting Wang Ming-Jun Zhao Jing Ma |
| author_sort | Lan-Shuan Feng |
| collection | DOAJ |
| description | The coexistence of anxiety or depression with coronary heart disease (CHD) is a significant clinical challenge in cardiovascular medicine. Recent studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activity could be a promising focus in understanding and addressing the development of treatments for comorbid CHD and anxiety or depression. The HPA axis helps to regulate the levels of inflammatory factors, thereby reducing oxidative stress damage, promoting platelet activation, and stabilizing gut microbiota, which enhance the survival and regeneration of neurons, endothelial cells, and other cell types, leading to neuroprotective and cardioprotective benefits. This review addresses the relevance of the HPA axis to the cardiovascular and nervous systems, as well as the latest research advancements regarding its mechanisms of action. The discussion includes a detailed function of the HPA axis in regulating the processes mentioned. Above all, it summarizes the therapeutic potential of HPA axis function as a biomarker for coronary atherosclerotic heart disease combined with anxiety or depression. |
| format | Article |
| id | doaj-art-118c19b45bfb4d32942adc59120b4ea0 |
| institution | DOAJ |
| issn | 0219-6352 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-118c19b45bfb4d32942adc59120b4ea02025-08-20T02:39:54ZengIMR PressJournal of Integrative Neuroscience0219-63522024-12-01231222210.31083/j.jin2312222S0219-6352(24)00854-4Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart DiseaseLan-Shuan Feng0Yi-Ming Wang1Huan Liu2Bo Ning3Hu-Bin Yu4Shi-Lin Li5Yu-Ting Wang6Ming-Jun Zhao7Jing Ma8First Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaFirst Clinical Medical College, Shaanxi University of Chinese Medicine, 712046 Xianyang, Shaanxi, ChinaThe coexistence of anxiety or depression with coronary heart disease (CHD) is a significant clinical challenge in cardiovascular medicine. Recent studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activity could be a promising focus in understanding and addressing the development of treatments for comorbid CHD and anxiety or depression. The HPA axis helps to regulate the levels of inflammatory factors, thereby reducing oxidative stress damage, promoting platelet activation, and stabilizing gut microbiota, which enhance the survival and regeneration of neurons, endothelial cells, and other cell types, leading to neuroprotective and cardioprotective benefits. This review addresses the relevance of the HPA axis to the cardiovascular and nervous systems, as well as the latest research advancements regarding its mechanisms of action. The discussion includes a detailed function of the HPA axis in regulating the processes mentioned. Above all, it summarizes the therapeutic potential of HPA axis function as a biomarker for coronary atherosclerotic heart disease combined with anxiety or depression.https://www.imrpress.com/journal/JIN/23/12/10.31083/j.jin2312222anxietychddepressionhpa axismechanism of action |
| spellingShingle | Lan-Shuan Feng Yi-Ming Wang Huan Liu Bo Ning Hu-Bin Yu Shi-Lin Li Yu-Ting Wang Ming-Jun Zhao Jing Ma Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease Journal of Integrative Neuroscience anxiety chd depression hpa axis mechanism of action |
| title | Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease |
| title_full | Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease |
| title_fullStr | Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease |
| title_full_unstemmed | Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease |
| title_short | Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease |
| title_sort | hyperactivity in the hypothalamic pituitary adrenal axis an invisible killer for anxiety and or depression in coronary artherosclerotic heart disease |
| topic | anxiety chd depression hpa axis mechanism of action |
| url | https://www.imrpress.com/journal/JIN/23/12/10.31083/j.jin2312222 |
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