Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts
Abstract Heterogeneity is an important feature of cognitive impairment in patients with Parkinson’s disease (PD), with emerging evidence linking insulin resistance to accelerated cognitive decline. Our investigation examined the relationship between the triglyceride-glucose (TyG) index-a marker of i...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01100-1 |
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| author | Huimin Cao Yuying Zhao Ziyi Chen Xiaoya Zou Xinyi Du Li Yi Yu Ai Hongzhou Zuo Oumei Cheng Parkinson’s Progression Markers Initiative |
| author_facet | Huimin Cao Yuying Zhao Ziyi Chen Xiaoya Zou Xinyi Du Li Yi Yu Ai Hongzhou Zuo Oumei Cheng Parkinson’s Progression Markers Initiative |
| author_sort | Huimin Cao |
| collection | DOAJ |
| description | Abstract Heterogeneity is an important feature of cognitive impairment in patients with Parkinson’s disease (PD), with emerging evidence linking insulin resistance to accelerated cognitive decline. Our investigation examined the relationship between the triglyceride-glucose (TyG) index-a marker of insulin resistance-and cognition and striatal dopamine transporter (DAT) alterations in PD through cross-sectional and longitudinal analyses. In the primary cohort, higher TyG correlated with lower Mini-Mental State Examination (MMSE) scores (p < 0.001) and increased dementia risk (p = 0.014). Longitudinal analysis in the PPMI cohort showed higher baseline TyG predicted greater Montreal Cognitive Assessment (MoCA) decline (p = 0.019) and reduced DAT activity in caudate (p = 0.033) and putamen (p = 0.019) over 4 years.DAT activity in the caudate mediated 24.1% of the TyG index’s longitudinal effect on MoCA scores, while the TyG index mediated 16.9% of CSF GLP-1R’s effect. These results highlight the TyG index as a potential biomarker for identifying PD patients at higher risk of cognitive impairment. |
| format | Article |
| id | doaj-art-118b78d12a4f4cc69632cd99833b3cbc |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-118b78d12a4f4cc69632cd99833b3cbc2025-08-20T03:45:57ZengNature Portfolionpj Parkinson's Disease2373-80572025-08-011111910.1038/s41531-025-01100-1Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohortsHuimin Cao0Yuying Zhao1Ziyi Chen2Xiaoya Zou3Xinyi Du4Li Yi5Yu Ai6Hongzhou Zuo7Oumei Cheng8Parkinson’s Progression Markers InitiativeDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical UniversityAbstract Heterogeneity is an important feature of cognitive impairment in patients with Parkinson’s disease (PD), with emerging evidence linking insulin resistance to accelerated cognitive decline. Our investigation examined the relationship between the triglyceride-glucose (TyG) index-a marker of insulin resistance-and cognition and striatal dopamine transporter (DAT) alterations in PD through cross-sectional and longitudinal analyses. In the primary cohort, higher TyG correlated with lower Mini-Mental State Examination (MMSE) scores (p < 0.001) and increased dementia risk (p = 0.014). Longitudinal analysis in the PPMI cohort showed higher baseline TyG predicted greater Montreal Cognitive Assessment (MoCA) decline (p = 0.019) and reduced DAT activity in caudate (p = 0.033) and putamen (p = 0.019) over 4 years.DAT activity in the caudate mediated 24.1% of the TyG index’s longitudinal effect on MoCA scores, while the TyG index mediated 16.9% of CSF GLP-1R’s effect. These results highlight the TyG index as a potential biomarker for identifying PD patients at higher risk of cognitive impairment.https://doi.org/10.1038/s41531-025-01100-1 |
| spellingShingle | Huimin Cao Yuying Zhao Ziyi Chen Xiaoya Zou Xinyi Du Li Yi Yu Ai Hongzhou Zuo Oumei Cheng Parkinson’s Progression Markers Initiative Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts npj Parkinson's Disease |
| title | Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts |
| title_full | Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts |
| title_fullStr | Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts |
| title_full_unstemmed | Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts |
| title_short | Triglyceride-glucose index predicts cognitive decline and striatal dopamine deficiency in Parkinson disease in two cohorts |
| title_sort | triglyceride glucose index predicts cognitive decline and striatal dopamine deficiency in parkinson disease in two cohorts |
| url | https://doi.org/10.1038/s41531-025-01100-1 |
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