Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors

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Main Authors: Lin Wei, Yang Hu, Licheng Bai, Chenxu Xiao, Zhang Liu, Yun You, Keke Wang, Yunyuan Huang, Junfei Zhu, Jun Weng, Wenling Zhou, Han Li, Honghe Zhao, Zhiyong Wu, Meng Mei, Zigong Wei
Format: Article
Language:English
Published: American Chemical Society 2025-01-01
Series:ACS Omega
Online Access:https://doi.org/10.1021/acsomega.4c06508
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author Lin Wei
Yang Hu
Licheng Bai
Chenxu Xiao
Zhang Liu
Yun You
Keke Wang
Yunyuan Huang
Junfei Zhu
Jun Weng
Wenling Zhou
Han Li
Honghe Zhao
Zhiyong Wu
Meng Mei
Zigong Wei
author_facet Lin Wei
Yang Hu
Licheng Bai
Chenxu Xiao
Zhang Liu
Yun You
Keke Wang
Yunyuan Huang
Junfei Zhu
Jun Weng
Wenling Zhou
Han Li
Honghe Zhao
Zhiyong Wu
Meng Mei
Zigong Wei
author_sort Lin Wei
collection DOAJ
format Article
id doaj-art-118758c96eb941e69f23ea9eb78512d5
institution Kabale University
issn 2470-1343
language English
publishDate 2025-01-01
publisher American Chemical Society
record_format Article
series ACS Omega
spelling doaj-art-118758c96eb941e69f23ea9eb78512d52025-02-04T09:14:23ZengAmerican Chemical SocietyACS Omega2470-13432025-01-011043389339710.1021/acsomega.4c06508Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase InhibitorsLin Wei0Yang Hu1Licheng Bai2Chenxu Xiao3Zhang Liu4Yun You5Keke Wang6Yunyuan Huang7Junfei Zhu8Jun Weng9Wenling Zhou10Han Li11Honghe Zhao12Zhiyong Wu13Meng Mei14Zigong Wei15State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaHubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, Hubei, PR Chinahttps://doi.org/10.1021/acsomega.4c06508
spellingShingle Lin Wei
Yang Hu
Licheng Bai
Chenxu Xiao
Zhang Liu
Yun You
Keke Wang
Yunyuan Huang
Junfei Zhu
Jun Weng
Wenling Zhou
Han Li
Honghe Zhao
Zhiyong Wu
Meng Mei
Zigong Wei
Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors
ACS Omega
title Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors
title_full Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors
title_fullStr Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors
title_full_unstemmed Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors
title_short Design of the Inhibitors for Pseudorabies Virus Replication by Reinforcement Learning from HSV‑1 DNA Polymerase Inhibitors
title_sort design of the inhibitors for pseudorabies virus replication by reinforcement learning from hsv 1 dna polymerase inhibitors
url https://doi.org/10.1021/acsomega.4c06508
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