Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up
ABSTRACT The Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI) study is a longitudinal prospective cohort of 50 participants at a single institution in Buenos Aires, Argentina. Longitudinal assessments on a neuropsychological test battery were performed on 15 controls, 24 mild co...
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| Series: | Arquivos de Neuro-Psiquiatria |
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| author | Patricio Chrem Méndez Ismael Calandri Federico Nahas María Julieta Russo Ignacio Demey María Eugenia Martín María Florencia Clarens Paula Harris Fernanda Tapajoz Jorge Campos Ezequiel I. Surace Horacio Martinetto Fernando Ventrice Gabriela Cohen Silvia Vázquez Carlos Romero Salvador Guinjoan Ricardo F. Allegri Gustavo Sevlever |
| author_facet | Patricio Chrem Méndez Ismael Calandri Federico Nahas María Julieta Russo Ignacio Demey María Eugenia Martín María Florencia Clarens Paula Harris Fernanda Tapajoz Jorge Campos Ezequiel I. Surace Horacio Martinetto Fernando Ventrice Gabriela Cohen Silvia Vázquez Carlos Romero Salvador Guinjoan Ricardo F. Allegri Gustavo Sevlever |
| author_sort | Patricio Chrem Méndez |
| collection | DOAJ |
| description | ABSTRACT The Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI) study is a longitudinal prospective cohort of 50 participants at a single institution in Buenos Aires, Argentina. Longitudinal assessments on a neuropsychological test battery were performed on 15 controls, 24 mild cognitive impairment (MCI) patients and 12 Alzheimer's disease (AD) dementia patients. In our study population, there was a high prevalence of positive AD biomarkers in the AD group, 92.3% (12/13); and a low prevalence in the normal controls, 20%; almost half (48%) of the patients diagnosed with MCI had positive amyloid detection. After a one year, the significant differences found at baseline on neuropsychological testing were similar at the follow-up assessment even though the AD group had significantly altered its functional performance (FAQ and CDR). The exception was semantic fluency, which showed greater impairment between the AD group and MCI and normal controls respectively. For these tests, the addition of AD biomarkers as a variable did not significantly alter the variations previously found for the established clinical group's model. Finally, the one-year conversion rate to dementia was 20% in the MCI cohort. |
| format | Article |
| id | doaj-art-1180bf2e51c8488491d6fa333b598d0e |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-1180bf2e51c8488491d6fa333b598d0e2025-08-20T02:01:54ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-422776423124010.1590/0004-282x20180025S0004-282X2018000400231Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow upPatricio Chrem MéndezIsmael CalandriFederico NahasMaría Julieta RussoIgnacio DemeyMaría Eugenia MartínMaría Florencia ClarensPaula HarrisFernanda TapajozJorge CamposEzequiel I. SuraceHoracio MartinettoFernando VentriceGabriela CohenSilvia VázquezCarlos RomeroSalvador GuinjoanRicardo F. AllegriGustavo SevleverABSTRACT The Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI) study is a longitudinal prospective cohort of 50 participants at a single institution in Buenos Aires, Argentina. Longitudinal assessments on a neuropsychological test battery were performed on 15 controls, 24 mild cognitive impairment (MCI) patients and 12 Alzheimer's disease (AD) dementia patients. In our study population, there was a high prevalence of positive AD biomarkers in the AD group, 92.3% (12/13); and a low prevalence in the normal controls, 20%; almost half (48%) of the patients diagnosed with MCI had positive amyloid detection. After a one year, the significant differences found at baseline on neuropsychological testing were similar at the follow-up assessment even though the AD group had significantly altered its functional performance (FAQ and CDR). The exception was semantic fluency, which showed greater impairment between the AD group and MCI and normal controls respectively. For these tests, the addition of AD biomarkers as a variable did not significantly alter the variations previously found for the established clinical group's model. Finally, the one-year conversion rate to dementia was 20% in the MCI cohort.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000400231&lng=en&tlng=enAlzheimer's diseasecognitive dysfunctionbiomarkersneuroimaging |
| spellingShingle | Patricio Chrem Méndez Ismael Calandri Federico Nahas María Julieta Russo Ignacio Demey María Eugenia Martín María Florencia Clarens Paula Harris Fernanda Tapajoz Jorge Campos Ezequiel I. Surace Horacio Martinetto Fernando Ventrice Gabriela Cohen Silvia Vázquez Carlos Romero Salvador Guinjoan Ricardo F. Allegri Gustavo Sevlever Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up Arquivos de Neuro-Psiquiatria Alzheimer's disease cognitive dysfunction biomarkers neuroimaging |
| title | Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up |
| title_full | Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up |
| title_fullStr | Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up |
| title_full_unstemmed | Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up |
| title_short | Argentina-Alzheimer's disease neuroimaging initiative (Arg-ADNI): neuropsychological evolution profile after one-year follow up |
| title_sort | argentina alzheimer s disease neuroimaging initiative arg adni neuropsychological evolution profile after one year follow up |
| topic | Alzheimer's disease cognitive dysfunction biomarkers neuroimaging |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000400231&lng=en&tlng=en |
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