HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS
Objectives: To identify homologous segments of human hemostatic and viral proteins and to assess the role of human hemostatic proteins in viral replication. Materials and Methods: The following viruses were chosen for comparison: influenza B (B/Astrakhan/2/2017), coronaviruses (Hcov229E and SARS-Co)...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2017-10-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/637 |
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| author | I. N. Zhilinskaya A. R. Prochukhanova A. V. Fadeev E. P. Kharchenko |
| author_facet | I. N. Zhilinskaya A. R. Prochukhanova A. V. Fadeev E. P. Kharchenko |
| author_sort | I. N. Zhilinskaya |
| collection | DOAJ |
| description | Objectives: To identify homologous segments of human hemostatic and viral proteins and to assess the role of human hemostatic proteins in viral replication. Materials and Methods: The following viruses were chosen for comparison: influenza B (B/Astrakhan/2/2017), coronaviruses (Hcov229E and SARS-Co), type 1 adenovirus (adenoid 71), measles (ICHINOSE-BA) and rubella (Therien). The primary structures of viral proteins and 41 human hemostatic proteins were obtained from open–access www.ncbi.nlm.nih. gov and www.nextprot.org databases, respectively. Sequence homology was determined by comparing 12-amino-acid segments. Those sequences identical in ≥ 8 positions were considered homologous. Results: The analysis shows that viral proteins contain segments which mimic a number of human hemostatic proteins. Most of these segments, except those of adenovirus proteins, are homologous with coagulation factors. The increase in viral virulence, as in case of SARS-Co, correlates with an increased number of segments homologous with hemostatic proteins. Conclusion: Hemostasis plays an important role in viral replication and pathogenesis. The conclusion is consistent with the literature data about the relationship of hemostasis and inflammatory response to viral infections. |
| format | Article |
| id | doaj-art-117f82f598e04e2cba49d5d9cb12efb1 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2017-10-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-117f82f598e04e2cba49d5d9cb12efb12025-08-20T03:44:23ZrusJournal InfectologyЖурнал инфектологии2072-67322017-10-0193819110.22625/2072-6732-2017-9-3-81-91580HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMSI. N. Zhilinskaya0A. R. Prochukhanova1A. V. Fadeev2E. P. Kharchenko3Science Research Institute of UnfluenzaScience Research Institute of UnfluenzaScience Research Institute of UnfluenzaInstitute of Evolutionary Physiology and Biochemistry named after I.M. SechenovObjectives: To identify homologous segments of human hemostatic and viral proteins and to assess the role of human hemostatic proteins in viral replication. Materials and Methods: The following viruses were chosen for comparison: influenza B (B/Astrakhan/2/2017), coronaviruses (Hcov229E and SARS-Co), type 1 adenovirus (adenoid 71), measles (ICHINOSE-BA) and rubella (Therien). The primary structures of viral proteins and 41 human hemostatic proteins were obtained from open–access www.ncbi.nlm.nih. gov and www.nextprot.org databases, respectively. Sequence homology was determined by comparing 12-amino-acid segments. Those sequences identical in ≥ 8 positions were considered homologous. Results: The analysis shows that viral proteins contain segments which mimic a number of human hemostatic proteins. Most of these segments, except those of adenovirus proteins, are homologous with coagulation factors. The increase in viral virulence, as in case of SARS-Co, correlates with an increased number of segments homologous with hemostatic proteins. Conclusion: Hemostasis plays an important role in viral replication and pathogenesis. The conclusion is consistent with the literature data about the relationship of hemostasis and inflammatory response to viral infections.https://journal.niidi.ru/jofin/article/view/637viral proteinshemostatic proteinsprotein primary structure |
| spellingShingle | I. N. Zhilinskaya A. R. Prochukhanova A. V. Fadeev E. P. Kharchenko HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS Журнал инфектологии viral proteins hemostatic proteins protein primary structure |
| title | HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS |
| title_full | HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS |
| title_fullStr | HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS |
| title_full_unstemmed | HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS |
| title_short | HOMOLOGY BETWEEN SEGMENTS OF HUMAN HEMOSTATIC PROTEINS AND PROTEINS OF VIRUSES WHICH CAUSE ACUTE RESPIRATORY INFECTIONS OR DISEASES WITH SIMILAR SYMPTOMS |
| title_sort | homology between segments of human hemostatic proteins and proteins of viruses which cause acute respiratory infections or diseases with similar symptoms |
| topic | viral proteins hemostatic proteins protein primary structure |
| url | https://journal.niidi.ru/jofin/article/view/637 |
| work_keys_str_mv | AT inzhilinskaya homologybetweensegmentsofhumanhemostaticproteinsandproteinsofviruseswhichcauseacuterespiratoryinfectionsordiseaseswithsimilarsymptoms AT arprochukhanova homologybetweensegmentsofhumanhemostaticproteinsandproteinsofviruseswhichcauseacuterespiratoryinfectionsordiseaseswithsimilarsymptoms AT avfadeev homologybetweensegmentsofhumanhemostaticproteinsandproteinsofviruseswhichcauseacuterespiratoryinfectionsordiseaseswithsimilarsymptoms AT epkharchenko homologybetweensegmentsofhumanhemostaticproteinsandproteinsofviruseswhichcauseacuterespiratoryinfectionsordiseaseswithsimilarsymptoms |