Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot
Abstract Red blood cell distribution width (RDW) is a prognostic factor in various disorders. This study aimed to assess the prognostic value of RDW in patients undergoing amputation for diabetic foot. We retrospectively analyzed data on 415 patients who underwent diabetic foot amputation between Ja...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85684-x |
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| author | Yeo Kwon Yoon Jae Han Park Hang Hwan Cho Dong Woo Shim Wonwoo Lee Seung Hwan Han Jin Woo Lee Kwang Hwan Park |
| author_facet | Yeo Kwon Yoon Jae Han Park Hang Hwan Cho Dong Woo Shim Wonwoo Lee Seung Hwan Han Jin Woo Lee Kwang Hwan Park |
| author_sort | Yeo Kwon Yoon |
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| description | Abstract Red blood cell distribution width (RDW) is a prognostic factor in various disorders. This study aimed to assess the prognostic value of RDW in patients undergoing amputation for diabetic foot. We retrospectively analyzed data on 415 patients who underwent diabetic foot amputation between January 2009 and January 2019. After establishing an optimal cutoff value of preoperative RDW for all-cause mortality, univariable and multivariable analyses with Cox proportional hazard model for survivorship and logistic regression analysis for prolonged hospital length of stay (> 30 days) were performed to identify significant prognostic factors. A preoperative RDW of 14.5% was the optimal cutoff value for predicting all-cause mortality. RDW ≥ 14.5% was significantly associated with increased all-cause mortality (hazard ratio, 2.55; 95% confidence interval [CI], 1.55–4.19; P < 0.001) on multivariable Cox proportional model analysis. Preoperative RDW ≥ 14.5% was also associated with a prolonged hospital length of stay after surgery (odds ratio, 2.17; 95% CI, 1.29–3.66; P = 0.004). Higher preoperative RDW was an independent predictive factor for increased all-cause mortality and prolonged hospital length of stay after diabetic foot amputation. These results suggest that RDW may be a useful laboratory parameter for risk stratification in patients undergoing amputation for diabetic foot. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-117f17ade93e49afbe2b58600345f9ad2025-02-09T12:32:29ZengNature PortfolioScientific Reports2045-23222025-02-0115111310.1038/s41598-025-85684-xRed blood cell distribution width is an independent predictor of mortality following amputation for diabetic footYeo Kwon Yoon0Jae Han Park1Hang Hwan Cho2Dong Woo Shim3Wonwoo Lee4Seung Hwan Han5Jin Woo Lee6Kwang Hwan Park7Department of Orthopaedic Surgery, Yongin Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Ulsan Yonsei HospitalDepartment of Orthopaedic Surgery, Yonsei Barun Orthopedic ClinicDepartment of Orthopaedic Surgery, Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Severance Hospital, Yonsei University College of MedicineDepartment of Orthopaedic Surgery, Severance Hospital, Yonsei University College of MedicineAbstract Red blood cell distribution width (RDW) is a prognostic factor in various disorders. This study aimed to assess the prognostic value of RDW in patients undergoing amputation for diabetic foot. We retrospectively analyzed data on 415 patients who underwent diabetic foot amputation between January 2009 and January 2019. After establishing an optimal cutoff value of preoperative RDW for all-cause mortality, univariable and multivariable analyses with Cox proportional hazard model for survivorship and logistic regression analysis for prolonged hospital length of stay (> 30 days) were performed to identify significant prognostic factors. A preoperative RDW of 14.5% was the optimal cutoff value for predicting all-cause mortality. RDW ≥ 14.5% was significantly associated with increased all-cause mortality (hazard ratio, 2.55; 95% confidence interval [CI], 1.55–4.19; P < 0.001) on multivariable Cox proportional model analysis. Preoperative RDW ≥ 14.5% was also associated with a prolonged hospital length of stay after surgery (odds ratio, 2.17; 95% CI, 1.29–3.66; P = 0.004). Higher preoperative RDW was an independent predictive factor for increased all-cause mortality and prolonged hospital length of stay after diabetic foot amputation. These results suggest that RDW may be a useful laboratory parameter for risk stratification in patients undergoing amputation for diabetic foot.https://doi.org/10.1038/s41598-025-85684-xDiabetic footAmputationRed blood cell distribution widthMortalityHospital length of stay |
| spellingShingle | Yeo Kwon Yoon Jae Han Park Hang Hwan Cho Dong Woo Shim Wonwoo Lee Seung Hwan Han Jin Woo Lee Kwang Hwan Park Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot Scientific Reports Diabetic foot Amputation Red blood cell distribution width Mortality Hospital length of stay |
| title | Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot |
| title_full | Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot |
| title_fullStr | Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot |
| title_full_unstemmed | Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot |
| title_short | Red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot |
| title_sort | red blood cell distribution width is an independent predictor of mortality following amputation for diabetic foot |
| topic | Diabetic foot Amputation Red blood cell distribution width Mortality Hospital length of stay |
| url | https://doi.org/10.1038/s41598-025-85684-x |
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