Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications
Abstract Electroconductive polymers are the materials of interest for the fabrication of electro-conductive tissues. Metal ions through the redox systems offer polymers with electrical conductivity. In this study, we processed a gelatin methacrylate (GelMA) network with gold nanoparticles (GNPs) thr...
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| Format: | Article |
| Language: | English |
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Springer
2024-07-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Online Access: | https://doi.org/10.1007/s10856-024-06808-9 |
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| author | Zahra Barabadi Asrin Bahmani Marzieh Jalalimonfared Milad Ashrafizadeh Morteza Rashtbar Esmaeel Sharifi Haili Tian |
| author_facet | Zahra Barabadi Asrin Bahmani Marzieh Jalalimonfared Milad Ashrafizadeh Morteza Rashtbar Esmaeel Sharifi Haili Tian |
| author_sort | Zahra Barabadi |
| collection | DOAJ |
| description | Abstract Electroconductive polymers are the materials of interest for the fabrication of electro-conductive tissues. Metal ions through the redox systems offer polymers with electrical conductivity. In this study, we processed a gelatin methacrylate (GelMA) network with gold nanoparticles (GNPs) through a redox system with parahydroxybenzaldehyde (PHB) or curcumin to enhance its electrical conductivity. Induction of the redox system with both PHB and curcumin into the GelMA, introduced some new functional groups into the polymeric network, as it has been confirmed by H-NMR and FTIR. These new bonds resulted in higher electro-conductivity when GNPs were added to the polymer. Higher electroactivity was achieved by PHB compared to the curcumin-induced redox system, and the addition of GNPs without redox system induction showed the lowest electroactivity. MTT was used to evaluate the biocompatibility of the resultant polymers, and the PHB-treated hydrogels showed higher proliferative effects on the cells. The findings of this study suggest that the introduction of a redox system by PHB in the GelMA network along with GNPs can contribute to the electrochemical properties of the material. This electroactivity can be advantageous for tissue engineering of electro-conductive tissues like cardiac and nervous tissues. Graphical Abstract |
| format | Article |
| id | doaj-art-117dd41a677348deb1ff77ce5d931d41 |
| institution | OA Journals |
| issn | 1573-4838 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-117dd41a677348deb1ff77ce5d931d412025-08-20T02:32:25ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382024-07-0135111210.1007/s10856-024-06808-9Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applicationsZahra Barabadi0Asrin Bahmani1Marzieh Jalalimonfared2Milad Ashrafizadeh3Morteza Rashtbar4Esmaeel Sharifi5Haili Tian6Research Center for Molecular Medicine, Hamadan University of Medical SciencesResearch Center for Molecular Medicine, Hamadan University of Medical SciencesDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical SciencesDepartment of General Surgery, Institute of Precision Diagnosis and Treatment of Digestive System Tumors, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen UniversityTabriz University of Medical SciencesResearch Center for Molecular Medicine, Hamadan University of Medical SciencesSchool of Exercise and Health, Shanghai University of SportAbstract Electroconductive polymers are the materials of interest for the fabrication of electro-conductive tissues. Metal ions through the redox systems offer polymers with electrical conductivity. In this study, we processed a gelatin methacrylate (GelMA) network with gold nanoparticles (GNPs) through a redox system with parahydroxybenzaldehyde (PHB) or curcumin to enhance its electrical conductivity. Induction of the redox system with both PHB and curcumin into the GelMA, introduced some new functional groups into the polymeric network, as it has been confirmed by H-NMR and FTIR. These new bonds resulted in higher electro-conductivity when GNPs were added to the polymer. Higher electroactivity was achieved by PHB compared to the curcumin-induced redox system, and the addition of GNPs without redox system induction showed the lowest electroactivity. MTT was used to evaluate the biocompatibility of the resultant polymers, and the PHB-treated hydrogels showed higher proliferative effects on the cells. The findings of this study suggest that the introduction of a redox system by PHB in the GelMA network along with GNPs can contribute to the electrochemical properties of the material. This electroactivity can be advantageous for tissue engineering of electro-conductive tissues like cardiac and nervous tissues. Graphical Abstracthttps://doi.org/10.1007/s10856-024-06808-9 |
| spellingShingle | Zahra Barabadi Asrin Bahmani Marzieh Jalalimonfared Milad Ashrafizadeh Morteza Rashtbar Esmaeel Sharifi Haili Tian Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications Journal of Materials Science: Materials in Medicine |
| title | Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications |
| title_full | Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications |
| title_fullStr | Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications |
| title_full_unstemmed | Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications |
| title_short | Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications |
| title_sort | design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications |
| url | https://doi.org/10.1007/s10856-024-06808-9 |
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