Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric Solution
We performed a prospective, double-blinded study in 20 patients undergoing gynecologic surgery with lower abdominal incision, to investigate characteristics of intrathecal hyperbaric levobupivacaine compared with isobaric levobupivacaine. We randomly assigned them to receive 3 mL of either isobaric...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/169076 |
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| author | Vimolluck Sanansilp Travuth Trivate Phakaporn Chompubai Shusee Visalyaputra Pattipa Suksopee Ladda Permpolprasert Benno von Bormann |
| author_facet | Vimolluck Sanansilp Travuth Trivate Phakaporn Chompubai Shusee Visalyaputra Pattipa Suksopee Ladda Permpolprasert Benno von Bormann |
| author_sort | Vimolluck Sanansilp |
| collection | DOAJ |
| description | We performed a prospective, double-blinded study in 20 patients undergoing gynecologic surgery with lower abdominal incision, to investigate characteristics of intrathecal hyperbaric levobupivacaine compared with isobaric levobupivacaine. We randomly assigned them to receive 3 mL of either isobaric or hyperbaric 0.42% levobupivacaine intrathecally. We found that hyperbaric levobupivacaine, compared with isobaric levobupivacaine, spread faster to T10 level (2.8 ± 1.1 versus 6.6 ± 4.7 minutes, 𝑃=0.039), reached higher sensory block levels at 5 and 15 minutes after injection (T8 versus L1, 𝑃=0.011, and T4 versus T7, 𝑃=0.027, resp.), and had a higher peak level (T4 versus T8, 𝑃=0.040). Isobaric levobupivacaine caused a wider range of peak levels (L1 to C8) compared with hyperbaric form (T7 to T2). The level of T4 or higher reached 90% in the hyperbaric group compared with 20% in the isobaric group (𝑃=0.005). Our results suggest that hyperbaric levobupivacaine was more predictable for sensory block level and more effective for surgical procedures with lower abdominal approach. Hyperbaric levobupivacaine seems to be suitable, but the optimal dosage needs further investigation. |
| format | Article |
| id | doaj-art-117b532d7dfd40cf99958e2e370f2fa4 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-117b532d7dfd40cf99958e2e370f2fa42025-02-03T01:30:01ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/169076169076Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric SolutionVimolluck Sanansilp0Travuth Trivate1Phakaporn Chompubai2Shusee Visalyaputra3Pattipa Suksopee4Ladda Permpolprasert5Benno von Bormann6Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, ThailandWe performed a prospective, double-blinded study in 20 patients undergoing gynecologic surgery with lower abdominal incision, to investigate characteristics of intrathecal hyperbaric levobupivacaine compared with isobaric levobupivacaine. We randomly assigned them to receive 3 mL of either isobaric or hyperbaric 0.42% levobupivacaine intrathecally. We found that hyperbaric levobupivacaine, compared with isobaric levobupivacaine, spread faster to T10 level (2.8 ± 1.1 versus 6.6 ± 4.7 minutes, 𝑃=0.039), reached higher sensory block levels at 5 and 15 minutes after injection (T8 versus L1, 𝑃=0.011, and T4 versus T7, 𝑃=0.027, resp.), and had a higher peak level (T4 versus T8, 𝑃=0.040). Isobaric levobupivacaine caused a wider range of peak levels (L1 to C8) compared with hyperbaric form (T7 to T2). The level of T4 or higher reached 90% in the hyperbaric group compared with 20% in the isobaric group (𝑃=0.005). Our results suggest that hyperbaric levobupivacaine was more predictable for sensory block level and more effective for surgical procedures with lower abdominal approach. Hyperbaric levobupivacaine seems to be suitable, but the optimal dosage needs further investigation.http://dx.doi.org/10.1100/2012/169076 |
| spellingShingle | Vimolluck Sanansilp Travuth Trivate Phakaporn Chompubai Shusee Visalyaputra Pattipa Suksopee Ladda Permpolprasert Benno von Bormann Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric Solution The Scientific World Journal |
| title | Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric Solution |
| title_full | Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric Solution |
| title_fullStr | Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric Solution |
| title_full_unstemmed | Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric Solution |
| title_short | Clinical Characteristics of Spinal Levobupivacaine: Hyperbaric Compared with Isobaric Solution |
| title_sort | clinical characteristics of spinal levobupivacaine hyperbaric compared with isobaric solution |
| url | http://dx.doi.org/10.1100/2012/169076 |
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