IL-27 effects on HIVGag-specific CD4 and CD8 T cell function

IL-27 effects on HIVGag-specific CD4 and CD8 T cell function

BackgroundIn people with HIV (PWH) and suppressed viral replication by antiretroviral therapy persistent T cell activation and inflammation are important contributors of the increased risk of morbidity and mortality. CD8 T cells express checkpoint receptors and are dysfunctional. IL-27, a member of...

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Bibliographic Details
Main Authors: Maryam Abdussamad, Grace Katz, Jie Cheng, Chinmayee Mehta, Fernando Andres-Martin, Danial Mahmood, Princy Kumar, Marta Catalfamo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Virology
Subjects:
IL27
HIV
T cell immune activation
HIV-specific T cells
IL-27 effects on T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fviro.2025.1600802/full
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