Predictors of Multiple Primary Malignancies: Literature Review
The present paper considers the predictors of multiple primary malignancies. The multiple primary malignancies are often induced by genetic predisposition and familial cancer syndromes, environmental carcinogens and bad habits (e.g. tobacco and alcohol abuse), immunodeficiency and infectious disease...
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| Format: | Article |
| Language: | English |
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Bashkir State Medical University
2023-10-01
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| Series: | Креативная хирургия и онкология |
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| Online Access: | https://www.surgonco.ru/jour/article/view/831 |
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| author | A. V. Sultanbaev K. V. Menshikov Sh. I. Musin A. A. Izmailov I. A. Menshikova N. I. Sultanbaeva |
| author_facet | A. V. Sultanbaev K. V. Menshikov Sh. I. Musin A. A. Izmailov I. A. Menshikova N. I. Sultanbaeva |
| author_sort | A. V. Sultanbaev |
| collection | DOAJ |
| description | The present paper considers the predictors of multiple primary malignancies. The multiple primary malignancies are often induced by genetic predisposition and familial cancer syndromes, environmental carcinogens and bad habits (e.g. tobacco and alcohol abuse), immunodeficiency and infectious diseases, carcinogens occurring as a result of various treatments, etc. Germinal mutations are considered to be one of the causes of primary cancer — they increase the risk of various multiple primary malignancies. Hereditary cancers are characterized by a strong family history, early age of onset and occurrence of multiple primary malignancies. The paper considers various mechanisms of multiple primary malignancies with an emphasis on the effect of carcinogens in carriers of pathogenic genes on cancer development. In proven cases, when patients are exposed to multiple carcinogens, they should be aware of possible late and long-term effects of treatment and their symptoms, as well as secondary malignancies that might occur. When the main predictors of carcinogenesis are manageable, and primary preventive measures can be taken, the hereditary malignancies require postexposure prophylaxis. In addition to specific recommendations for the prevention of primary cancers, it is essential to follow recommendations for the prevention of second primary cancers. |
| format | Article |
| id | doaj-art-1177b006da774b07b78aa0ebe285b268 |
| institution | Kabale University |
| issn | 2076-3093 2307-0501 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj-art-1177b006da774b07b78aa0ebe285b2682025-08-20T03:57:27ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012023-10-0113322122810.24060/2076-3093-2023-13-3-221-228538Predictors of Multiple Primary Malignancies: Literature ReviewA. V. Sultanbaev0K. V. Menshikov1Sh. I. Musin2A. A. Izmailov3I. A. Menshikova4N. I. Sultanbaeva5Republican Clinical Oncology DispensaryRepublican Clinical Oncology Dispensary; Bashkir State Medical UniversityRepublican Clinical Oncology DispensaryRepublican Clinical Oncology DispensaryBashkir State Medical UniversityRepublican Clinical Oncology DispensaryThe present paper considers the predictors of multiple primary malignancies. The multiple primary malignancies are often induced by genetic predisposition and familial cancer syndromes, environmental carcinogens and bad habits (e.g. tobacco and alcohol abuse), immunodeficiency and infectious diseases, carcinogens occurring as a result of various treatments, etc. Germinal mutations are considered to be one of the causes of primary cancer — they increase the risk of various multiple primary malignancies. Hereditary cancers are characterized by a strong family history, early age of onset and occurrence of multiple primary malignancies. The paper considers various mechanisms of multiple primary malignancies with an emphasis on the effect of carcinogens in carriers of pathogenic genes on cancer development. In proven cases, when patients are exposed to multiple carcinogens, they should be aware of possible late and long-term effects of treatment and their symptoms, as well as secondary malignancies that might occur. When the main predictors of carcinogenesis are manageable, and primary preventive measures can be taken, the hereditary malignancies require postexposure prophylaxis. In addition to specific recommendations for the prevention of primary cancers, it is essential to follow recommendations for the prevention of second primary cancers.https://www.surgonco.ru/jour/article/view/831multiple primary malignanciesgerminal mutationsgermline mutationscarcinogenesisdnachemotherapyradiotherapy |
| spellingShingle | A. V. Sultanbaev K. V. Menshikov Sh. I. Musin A. A. Izmailov I. A. Menshikova N. I. Sultanbaeva Predictors of Multiple Primary Malignancies: Literature Review Креативная хирургия и онкология multiple primary malignancies germinal mutations germline mutations carcinogenesis dna chemotherapy radiotherapy |
| title | Predictors of Multiple Primary Malignancies: Literature Review |
| title_full | Predictors of Multiple Primary Malignancies: Literature Review |
| title_fullStr | Predictors of Multiple Primary Malignancies: Literature Review |
| title_full_unstemmed | Predictors of Multiple Primary Malignancies: Literature Review |
| title_short | Predictors of Multiple Primary Malignancies: Literature Review |
| title_sort | predictors of multiple primary malignancies literature review |
| topic | multiple primary malignancies germinal mutations germline mutations carcinogenesis dna chemotherapy radiotherapy |
| url | https://www.surgonco.ru/jour/article/view/831 |
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