An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules
Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely ex...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2018/8547364 |
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| author | Aiten Ismailova David Kuter D. Scott Bohle Ian S. Butler |
| author_facet | Aiten Ismailova David Kuter D. Scott Bohle Ian S. Butler |
| author_sort | Aiten Ismailova |
| collection | DOAJ |
| description | Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called “carbon monoxide releasing molecules (CORMs).” This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs. |
| format | Article |
| id | doaj-art-117182ce09a4484cb7e32b4f5dc2ec63 |
| institution | OA Journals |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-117182ce09a4484cb7e32b4f5dc2ec632025-08-20T02:01:54ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2018-01-01201810.1155/2018/85473648547364An Overview of the Potential Therapeutic Applications of CO-Releasing MoleculesAiten Ismailova0David Kuter1D. Scott Bohle2Ian S. Butler3Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 3K6, CanadaDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 3K6, CanadaDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 3K6, CanadaDepartment of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, QC, H3A 3K6, CanadaCarbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an endogenous neurotransmitter, however, was suggested in the early 1990s. Since then, the biological activity of CO has been widely examined via both the direct administration of CO and in the form of so-called “carbon monoxide releasing molecules (CORMs).” This overview will explore the general physiological effects and potential therapeutic applications of CO when delivered in the form of CORMs.http://dx.doi.org/10.1155/2018/8547364 |
| spellingShingle | Aiten Ismailova David Kuter D. Scott Bohle Ian S. Butler An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules Bioinorganic Chemistry and Applications |
| title | An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules |
| title_full | An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules |
| title_fullStr | An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules |
| title_full_unstemmed | An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules |
| title_short | An Overview of the Potential Therapeutic Applications of CO-Releasing Molecules |
| title_sort | overview of the potential therapeutic applications of co releasing molecules |
| url | http://dx.doi.org/10.1155/2018/8547364 |
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