The Role of PPAR Gamma in Systemic Sclerosis
Fibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting the skin and multiple internal organs. SSc has a...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2015/124624 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550253543292928 |
|---|---|
| author | Andréa Tavares Dantas Michelly Cristiny Pereira Moacyr Jesus Barreto de Melo Rego Laurindo Ferreira da Rocha Ivan da Rocha Pitta Cláudia Diniz Lopes Marques Angela Luzia Branco Pinto Duarte Maira Galdino da Rocha Pitta |
| author_facet | Andréa Tavares Dantas Michelly Cristiny Pereira Moacyr Jesus Barreto de Melo Rego Laurindo Ferreira da Rocha Ivan da Rocha Pitta Cláudia Diniz Lopes Marques Angela Luzia Branco Pinto Duarte Maira Galdino da Rocha Pitta |
| author_sort | Andréa Tavares Dantas |
| collection | DOAJ |
| description | Fibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting the skin and multiple internal organs. SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need. Recently, antifibrotic effects of PPARγ ligands have been studied in vitro and in vivo and some theories have emerged leading to new insights. Aberrant PPARγ function seems to be implicated in pathological fibrosis in the skin and lungs. This antifibrotic effect is mainly related to the inhibition of TGF-β/Smad signal transduction but other pathways can be involved. This review focused on recent studies that identified PPARγ as an important novel pathway with critical roles in regulating connective tissue homeostasis, with emphasis on skin and lung fibrosis and its role on systemic sclerosis. |
| format | Article |
| id | doaj-art-116a948468fe4c35a6320f053db4104e |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-116a948468fe4c35a6320f053db4104e2025-02-03T06:07:16ZengWileyPPAR Research1687-47571687-47652015-01-01201510.1155/2015/124624124624The Role of PPAR Gamma in Systemic SclerosisAndréa Tavares Dantas0Michelly Cristiny Pereira1Moacyr Jesus Barreto de Melo Rego2Laurindo Ferreira da Rocha3Ivan da Rocha Pitta4Cláudia Diniz Lopes Marques5Angela Luzia Branco Pinto Duarte6Maira Galdino da Rocha Pitta7Serviço de Reumatologia do Hospital das Clínicas da Universidade Federal de Pernambuco (HC-UFPE), 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas da Universidade Federal de Pernambuco (LINAT-UFPE), 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas da Universidade Federal de Pernambuco (LINAT-UFPE), 50670-901 Recife, PE, BrazilServiço de Reumatologia do Hospital das Clínicas da Universidade Federal de Pernambuco (HC-UFPE), 50670-901 Recife, PE, BrazilLaboratório de Planejamento e Síntese de Fármacos da Universidade Federal de Pernambuco (LPSF-UFPE), 50670-901 Recife, PE, BrazilServiço de Reumatologia do Hospital das Clínicas da Universidade Federal de Pernambuco (HC-UFPE), 50670-901 Recife, PE, BrazilServiço de Reumatologia do Hospital das Clínicas da Universidade Federal de Pernambuco (HC-UFPE), 50670-901 Recife, PE, BrazilLaboratório de Imunomodulação e Novas Abordagens Terapêuticas da Universidade Federal de Pernambuco (LINAT-UFPE), 50670-901 Recife, PE, BrazilFibrosis is recognized as an important feature of many chronic diseases, such as systemic sclerosis (SSc), an autoimmune disease of unknown etiology, characterized by immune dysregulation and vascular injury, followed by progressive fibrosis affecting the skin and multiple internal organs. SSc has a poor prognosis because no therapy has been shown to reverse or arrest the progression of fibrosis, representing a major unmet medical need. Recently, antifibrotic effects of PPARγ ligands have been studied in vitro and in vivo and some theories have emerged leading to new insights. Aberrant PPARγ function seems to be implicated in pathological fibrosis in the skin and lungs. This antifibrotic effect is mainly related to the inhibition of TGF-β/Smad signal transduction but other pathways can be involved. This review focused on recent studies that identified PPARγ as an important novel pathway with critical roles in regulating connective tissue homeostasis, with emphasis on skin and lung fibrosis and its role on systemic sclerosis.http://dx.doi.org/10.1155/2015/124624 |
| spellingShingle | Andréa Tavares Dantas Michelly Cristiny Pereira Moacyr Jesus Barreto de Melo Rego Laurindo Ferreira da Rocha Ivan da Rocha Pitta Cláudia Diniz Lopes Marques Angela Luzia Branco Pinto Duarte Maira Galdino da Rocha Pitta The Role of PPAR Gamma in Systemic Sclerosis PPAR Research |
| title | The Role of PPAR Gamma in Systemic Sclerosis |
| title_full | The Role of PPAR Gamma in Systemic Sclerosis |
| title_fullStr | The Role of PPAR Gamma in Systemic Sclerosis |
| title_full_unstemmed | The Role of PPAR Gamma in Systemic Sclerosis |
| title_short | The Role of PPAR Gamma in Systemic Sclerosis |
| title_sort | role of ppar gamma in systemic sclerosis |
| url | http://dx.doi.org/10.1155/2015/124624 |
| work_keys_str_mv | AT andreatavaresdantas theroleofppargammainsystemicsclerosis AT michellycristinypereira theroleofppargammainsystemicsclerosis AT moacyrjesusbarretodemelorego theroleofppargammainsystemicsclerosis AT laurindoferreiradarocha theroleofppargammainsystemicsclerosis AT ivandarochapitta theroleofppargammainsystemicsclerosis AT claudiadinizlopesmarques theroleofppargammainsystemicsclerosis AT angelaluziabrancopintoduarte theroleofppargammainsystemicsclerosis AT mairagaldinodarochapitta theroleofppargammainsystemicsclerosis AT andreatavaresdantas roleofppargammainsystemicsclerosis AT michellycristinypereira roleofppargammainsystemicsclerosis AT moacyrjesusbarretodemelorego roleofppargammainsystemicsclerosis AT laurindoferreiradarocha roleofppargammainsystemicsclerosis AT ivandarochapitta roleofppargammainsystemicsclerosis AT claudiadinizlopesmarques roleofppargammainsystemicsclerosis AT angelaluziabrancopintoduarte roleofppargammainsystemicsclerosis AT mairagaldinodarochapitta roleofppargammainsystemicsclerosis |