Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration
Abstract Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated tissues still poses significant challenges due to the lack of concerns of tissue innerva...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202415344 |
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| author | Hongjian Zhang Ziyi Zhao Chengtie Wu |
| author_facet | Hongjian Zhang Ziyi Zhao Chengtie Wu |
| author_sort | Hongjian Zhang |
| collection | DOAJ |
| description | Abstract Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated tissues still poses significant challenges due to the lack of concerns of tissue innervation. Design rationale of multifunctional biomaterials with both tissue‐induction and neural induction activities shows great potential for functional tissue regeneration. Recently, the research and application of inorganic biomaterials attracts increasing attention in innervated multi‐tissue regeneration, such as central nerves, bone, and skin, because of its superior tunable chemical composition, topographical structures, and physiochemical properties. More importantly, inorganic biomaterials are easily combined with other organic materials, biological factors, and external stimuli to enhance their therapeutic effects. This review presents a comprehensive overview of recent advancements of inorganic biomaterials for innervated multi‐tissue regeneration. It begins with introducing classification and properties of typical inorganic biomaterials and design rationale of inorganic‐based material composites. Then, recent progresses of inorganic biomaterials in regenerating various nerves and nerve‐innervated tissues with functional recovery are systematically reviewed. Finally, the existing challenges and future perspectives are proposed. This review may pave the way for the direction of inorganic biomaterials and offers a new strategy for tissue regeneration in combination of innervation. |
| format | Article |
| id | doaj-art-116463ed47eb4d808ddd13eb289284e2 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-116463ed47eb4d808ddd13eb289284e22025-08-20T03:16:56ZengWileyAdvanced Science2198-38442025-04-011213n/an/a10.1002/advs.202415344Bioactive Inorganic Materials for Innervated Multi‐Tissue RegenerationHongjian Zhang0Ziyi Zhao1Chengtie Wu2State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaAbstract Tissue engineering aims to repair damaged tissues with physiological functions recovery. Although several therapeutic strategies are there for tissue regeneration, the functional recovery of regenerated tissues still poses significant challenges due to the lack of concerns of tissue innervation. Design rationale of multifunctional biomaterials with both tissue‐induction and neural induction activities shows great potential for functional tissue regeneration. Recently, the research and application of inorganic biomaterials attracts increasing attention in innervated multi‐tissue regeneration, such as central nerves, bone, and skin, because of its superior tunable chemical composition, topographical structures, and physiochemical properties. More importantly, inorganic biomaterials are easily combined with other organic materials, biological factors, and external stimuli to enhance their therapeutic effects. This review presents a comprehensive overview of recent advancements of inorganic biomaterials for innervated multi‐tissue regeneration. It begins with introducing classification and properties of typical inorganic biomaterials and design rationale of inorganic‐based material composites. Then, recent progresses of inorganic biomaterials in regenerating various nerves and nerve‐innervated tissues with functional recovery are systematically reviewed. Finally, the existing challenges and future perspectives are proposed. This review may pave the way for the direction of inorganic biomaterials and offers a new strategy for tissue regeneration in combination of innervation.https://doi.org/10.1002/advs.202415344functional recoveryinorganic biomaterialsinnervated tissue regenerationtissue engineering and regenerative medicine |
| spellingShingle | Hongjian Zhang Ziyi Zhao Chengtie Wu Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration Advanced Science functional recovery inorganic biomaterials innervated tissue regeneration tissue engineering and regenerative medicine |
| title | Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration |
| title_full | Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration |
| title_fullStr | Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration |
| title_full_unstemmed | Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration |
| title_short | Bioactive Inorganic Materials for Innervated Multi‐Tissue Regeneration |
| title_sort | bioactive inorganic materials for innervated multi tissue regeneration |
| topic | functional recovery inorganic biomaterials innervated tissue regeneration tissue engineering and regenerative medicine |
| url | https://doi.org/10.1002/advs.202415344 |
| work_keys_str_mv | AT hongjianzhang bioactiveinorganicmaterialsforinnervatedmultitissueregeneration AT ziyizhao bioactiveinorganicmaterialsforinnervatedmultitissueregeneration AT chengtiewu bioactiveinorganicmaterialsforinnervatedmultitissueregeneration |