Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney Disease
Information about parathyroid hormone (PTH) status in the course of AKI is lacking. In contrast, renal secondary hyperparathyroidism (RSHPT) is a well-known consequence of canine chronic kidney disease (CKD). This study aimed to investigate PTH status in dogs affected by AKI, comparing PTH concentra...
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MDPI AG
2025-02-01
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| Series: | Veterinary Sciences |
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| author | Jari Zambarbieri Erika Monari Francesco Dondi Pierangelo Moretti Alessia Giordano Paola Scarpa |
| author_facet | Jari Zambarbieri Erika Monari Francesco Dondi Pierangelo Moretti Alessia Giordano Paola Scarpa |
| author_sort | Jari Zambarbieri |
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| description | Information about parathyroid hormone (PTH) status in the course of AKI is lacking. In contrast, renal secondary hyperparathyroidism (RSHPT) is a well-known consequence of canine chronic kidney disease (CKD). This study aimed to investigate PTH status in dogs affected by AKI, comparing PTH concentrations between healthy dogs, dogs affected by AKI and dogs affected by CKD. Three groups of dogs (35 affected by AKI, 35 affected by CKD and 41 healthy) were retrospectively included. PTH concentrations were significantly higher in both the AKI and CKD groups (<i>p</i> < 0.0001) compared to healthy ones but without significant differences between the AKI and CKD groups. In the AKI group, increased PTH was detected in 88.6% of dogs. Moreover, in AKI dogs, PTH increases with AKI grading and is correlated with serum creatinine (<i>p</i> < 0.0001; r = 0.67) and phosphate concentrations (<i>p</i> < 0.0001; r = 0.74). PTH in AKI dogs was not correlated with total calcium (tCa), while it was negatively correlated with ionized calcium (iCa) (<i>p</i> < 0.0037; r = −0.53). Higher PTH concentrations also occurred in canine AKI, as reported in canine CKD and human AKI, presumably as a rapid response to ionized hypocalcemia and hyperphosphatemia, frequently reported in our patients. PTH seems not to be a useful tool in distinguishing AKI and CKD. |
| format | Article |
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| institution | DOAJ |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-115f7dcdd5da487f83c59ee0767457c82025-08-20T03:11:18ZengMDPI AGVeterinary Sciences2306-73812025-02-0112213110.3390/vetsci12020131Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney DiseaseJari Zambarbieri0Erika Monari1Francesco Dondi2Pierangelo Moretti3Alessia Giordano4Paola Scarpa5Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyDepartment of Veterinary Medical Sciences, Alma Mater Studiorum—University of Bologna, Via Tolara di Sopra n 50, 40064 Ozzano dell’Emilia, ItalyDepartment of Veterinary Medical Sciences, Alma Mater Studiorum—University of Bologna, Via Tolara di Sopra n 50, 40064 Ozzano dell’Emilia, ItalyDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, University of Milan, Via dell’Università 6, 26900 Lodi, ItalyInformation about parathyroid hormone (PTH) status in the course of AKI is lacking. In contrast, renal secondary hyperparathyroidism (RSHPT) is a well-known consequence of canine chronic kidney disease (CKD). This study aimed to investigate PTH status in dogs affected by AKI, comparing PTH concentrations between healthy dogs, dogs affected by AKI and dogs affected by CKD. Three groups of dogs (35 affected by AKI, 35 affected by CKD and 41 healthy) were retrospectively included. PTH concentrations were significantly higher in both the AKI and CKD groups (<i>p</i> < 0.0001) compared to healthy ones but without significant differences between the AKI and CKD groups. In the AKI group, increased PTH was detected in 88.6% of dogs. Moreover, in AKI dogs, PTH increases with AKI grading and is correlated with serum creatinine (<i>p</i> < 0.0001; r = 0.67) and phosphate concentrations (<i>p</i> < 0.0001; r = 0.74). PTH in AKI dogs was not correlated with total calcium (tCa), while it was negatively correlated with ionized calcium (iCa) (<i>p</i> < 0.0037; r = −0.53). Higher PTH concentrations also occurred in canine AKI, as reported in canine CKD and human AKI, presumably as a rapid response to ionized hypocalcemia and hyperphosphatemia, frequently reported in our patients. PTH seems not to be a useful tool in distinguishing AKI and CKD.https://www.mdpi.com/2306-7381/12/2/131parathyroid hormonehyperparathyroidismdogacute kidney injurychronic kidney disease |
| spellingShingle | Jari Zambarbieri Erika Monari Francesco Dondi Pierangelo Moretti Alessia Giordano Paola Scarpa Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney Disease Veterinary Sciences parathyroid hormone hyperparathyroidism dog acute kidney injury chronic kidney disease |
| title | Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney Disease |
| title_full | Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney Disease |
| title_fullStr | Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney Disease |
| title_full_unstemmed | Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney Disease |
| title_short | Parathyroid Hormone Concentration in Dogs Affected by Acute Kidney Injury Compared with Healthy and Chronic Kidney Disease |
| title_sort | parathyroid hormone concentration in dogs affected by acute kidney injury compared with healthy and chronic kidney disease |
| topic | parathyroid hormone hyperparathyroidism dog acute kidney injury chronic kidney disease |
| url | https://www.mdpi.com/2306-7381/12/2/131 |
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