HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation

HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation

Abstract The APOBEC3 family of cytidine deaminases restricts retroviruses like HIV-1 by mutating viral DNA. HIV-1 evades this restriction by producing Vif, which recruits the Cullin-5 (CUL5) E3 ubiquitin ligase complex to promote APOBEC3 degradation. Here we resolve key aspects of this counter-defen...

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Main Authors: Katarzyna A. Skorupka, Kazuhiro Matsuoka, Bakar Hassan, Rodolfo Ghirlando, Vanivilasini Balachandran, Ting-Hua Chen, Kylie J. Walters, Celia A. Schiffer, Matthias Wolf, Yasumasa Iwatani, Hiroshi Matsuo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60984-y
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