Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024
BackgroundThis study aims to investigate the distribution and drug resistance of Gram-negative bacteria in the intensive care unit (ICU) of a tertiary general hospital in Sichuan Province, with the goal of promoting rational antibiotic use and reducing multidrug resistance.MethodsA retrospective ana...
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Frontiers Media S.A.
2025-05-01
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| author | Xiaoying Chen Xin Liu Wenyan Ren Hongyan Li Siyun Yang |
| author_facet | Xiaoying Chen Xin Liu Wenyan Ren Hongyan Li Siyun Yang |
| author_sort | Xiaoying Chen |
| collection | DOAJ |
| description | BackgroundThis study aims to investigate the distribution and drug resistance of Gram-negative bacteria in the intensive care unit (ICU) of a tertiary general hospital in Sichuan Province, with the goal of promoting rational antibiotic use and reducing multidrug resistance.MethodsA retrospective analysis was conducted on the distribution and drug resistance of Gram-negative bacteria in ICU samples collected from January 2019 to December 2024.ResultsA total of 83,944 culture samples were analyzed, primarily blood (45.27%) and sputum (41.34%) specimens, with a steady increase in sample types annually. A total of 7,211 strains were isolated, 76.43% of which were from respiratory tract specimens. The predominant pathogens included Klebsiella pneumoniae (31.17%), Acinetobacter baumannii (30.11%), Escherichia coli (14.05%), and Pseudomonas aeruginosa (11.34%). The detection rates for carbapenem-resistant A. baumannii (CRAB) were 61.88%, carbapenem-resistant K. pneumoniae (CRKP) 29.28%, carbapenem-resistant P. aeruginosa (CRPA) 5.80%, and carbapenem-resistant E. coli (CREC) 3.04%. Susceptibility testing revealed fluctuating resistance rates for E. coli over the past 6 years. Notably, K. pneumoniae exhibited significant resistance to carbapenems (e.g., imipenem) and third-generation cephalosporins (e.g., ceftazidime).ConclusionFrom 2019 to 2024, the ICU experienced a severe problem with Gram-negative drug-resistant bacteria, particularly Enterobacteriaceae resistant to third-generation cephalosporins. A. baumannii isolates demonstrated resistance to most antibiotics, underscoring the need for continuous monitoring and the selection of effective antibiotics based on clinical practice. |
| format | Article |
| id | doaj-art-115b4b8e33ea435d9c84432d9851e7f3 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj-art-115b4b8e33ea435d9c84432d9851e7f32025-08-20T02:31:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-05-011610.3389/fmicb.2025.15871321587132Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024Xiaoying Chen0Xin Liu1Wenyan Ren2Hongyan Li3Siyun Yang4Department of Pharmacy, Nanchong Key Laboratory of Individualized Drug Therapy, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, ChinaDepartment of Pharmacy, Nanchong Key Laboratory of Individualized Drug Therapy, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, ChinaDepartment of Pharmacy, Nanchong Key Laboratory of Individualized Drug Therapy, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, ChinaDepartment of Laboratory, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, ChinaDepartment of Pharmacy, Nanchong Key Laboratory of Individualized Drug Therapy, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, ChinaBackgroundThis study aims to investigate the distribution and drug resistance of Gram-negative bacteria in the intensive care unit (ICU) of a tertiary general hospital in Sichuan Province, with the goal of promoting rational antibiotic use and reducing multidrug resistance.MethodsA retrospective analysis was conducted on the distribution and drug resistance of Gram-negative bacteria in ICU samples collected from January 2019 to December 2024.ResultsA total of 83,944 culture samples were analyzed, primarily blood (45.27%) and sputum (41.34%) specimens, with a steady increase in sample types annually. A total of 7,211 strains were isolated, 76.43% of which were from respiratory tract specimens. The predominant pathogens included Klebsiella pneumoniae (31.17%), Acinetobacter baumannii (30.11%), Escherichia coli (14.05%), and Pseudomonas aeruginosa (11.34%). The detection rates for carbapenem-resistant A. baumannii (CRAB) were 61.88%, carbapenem-resistant K. pneumoniae (CRKP) 29.28%, carbapenem-resistant P. aeruginosa (CRPA) 5.80%, and carbapenem-resistant E. coli (CREC) 3.04%. Susceptibility testing revealed fluctuating resistance rates for E. coli over the past 6 years. Notably, K. pneumoniae exhibited significant resistance to carbapenems (e.g., imipenem) and third-generation cephalosporins (e.g., ceftazidime).ConclusionFrom 2019 to 2024, the ICU experienced a severe problem with Gram-negative drug-resistant bacteria, particularly Enterobacteriaceae resistant to third-generation cephalosporins. A. baumannii isolates demonstrated resistance to most antibiotics, underscoring the need for continuous monitoring and the selection of effective antibiotics based on clinical practice.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1587132/fullintensive care unit (ICU)Gram-negative bacteriaantimicrobial agentsantibiotic resistancedistribution patterns |
| spellingShingle | Xiaoying Chen Xin Liu Wenyan Ren Hongyan Li Siyun Yang Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 Frontiers in Microbiology intensive care unit (ICU) Gram-negative bacteria antimicrobial agents antibiotic resistance distribution patterns |
| title | Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 |
| title_full | Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 |
| title_fullStr | Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 |
| title_full_unstemmed | Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 |
| title_short | Distribution patterns and evolution of antimicrobial resistance in Gram-negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 |
| title_sort | distribution patterns and evolution of antimicrobial resistance in gram negative bacteria within the intensive care unit of a tertiary hospital from 2019 to 2024 |
| topic | intensive care unit (ICU) Gram-negative bacteria antimicrobial agents antibiotic resistance distribution patterns |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1587132/full |
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