Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke
The endothelial dysfunction, associated with inflammation and vascular permeability, remains the key event in the pathogenesis of cerebral ischemic stroke. Angiogenesis is essential for neuroprotection and neural repair following stroke. The neuroinflammatory reaction plays a vital role in stroke, a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/7006281 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551094337667072 |
|---|---|
| author | Yongdan Cun Yaju Jin Danli Wu Li Zhou Chengcai Zhang Simei Zhang Xicheng Yang null Zuhong Wang Pengyue Zhang |
| author_facet | Yongdan Cun Yaju Jin Danli Wu Li Zhou Chengcai Zhang Simei Zhang Xicheng Yang null Zuhong Wang Pengyue Zhang |
| author_sort | Yongdan Cun |
| collection | DOAJ |
| description | The endothelial dysfunction, associated with inflammation and vascular permeability, remains the key event in the pathogenesis of cerebral ischemic stroke. Angiogenesis is essential for neuroprotection and neural repair following stroke. The neuroinflammatory reaction plays a vital role in stroke, and inhibition of inflammation contributes to establishing an appropriate external environment for angiogenesis. Exosomes are the heterogeneous population of extracellular vesicles which play critical roles in intercellular communication through transmitting various proteins and nucleic acids to nearby and distant recipient cells by body fluids and circulation. Recent reports have shown that exosomal therapy is a valuable and potential treatment strategy for stroke. In this review, we discussed the exosomes in complex interaction mechanisms of angiogenesis and inflammation following stroke as well as the challenges of exosomal studies such as secretion, uptake, modification, and application. |
| format | Article |
| id | doaj-art-1155c4297f1541c582ef998aa5ab9146 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1155c4297f1541c582ef998aa5ab91462025-02-03T06:04:53ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/7006281Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for StrokeYongdan Cun0Yaju Jin1Danli Wu2Li Zhou3Chengcai Zhang4Simei Zhang5Xicheng Yang6null Zuhong Wang7Pengyue Zhang8Key Laboratory of Acupuncture and Massage for Treatment of EncephalopathyKey Laboratory of Acupuncture and Massage for Treatment of EncephalopathyKey Laboratory of Acupuncture and Massage for Treatment of EncephalopathyKey Laboratory of Acupuncture and Massage for Treatment of EncephalopathyKey Laboratory of Acupuncture and Massage for Treatment of EncephalopathyKey Laboratory of Acupuncture and Massage for Treatment of EncephalopathyKey Laboratory of Acupuncture and Massage for Treatment of EncephalopathyAcupuncture DepartmentKey Laboratory of Acupuncture and Massage for Treatment of EncephalopathyThe endothelial dysfunction, associated with inflammation and vascular permeability, remains the key event in the pathogenesis of cerebral ischemic stroke. Angiogenesis is essential for neuroprotection and neural repair following stroke. The neuroinflammatory reaction plays a vital role in stroke, and inhibition of inflammation contributes to establishing an appropriate external environment for angiogenesis. Exosomes are the heterogeneous population of extracellular vesicles which play critical roles in intercellular communication through transmitting various proteins and nucleic acids to nearby and distant recipient cells by body fluids and circulation. Recent reports have shown that exosomal therapy is a valuable and potential treatment strategy for stroke. In this review, we discussed the exosomes in complex interaction mechanisms of angiogenesis and inflammation following stroke as well as the challenges of exosomal studies such as secretion, uptake, modification, and application.http://dx.doi.org/10.1155/2022/7006281 |
| spellingShingle | Yongdan Cun Yaju Jin Danli Wu Li Zhou Chengcai Zhang Simei Zhang Xicheng Yang null Zuhong Wang Pengyue Zhang Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke Mediators of Inflammation |
| title | Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke |
| title_full | Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke |
| title_fullStr | Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke |
| title_full_unstemmed | Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke |
| title_short | Exosome in Crosstalk between Inflammation and Angiogenesis: A Potential Therapeutic Strategy for Stroke |
| title_sort | exosome in crosstalk between inflammation and angiogenesis a potential therapeutic strategy for stroke |
| url | http://dx.doi.org/10.1155/2022/7006281 |
| work_keys_str_mv | AT yongdancun exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT yajujin exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT danliwu exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT lizhou exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT chengcaizhang exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT simeizhang exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT xichengyang exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT nullzuhongwang exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke AT pengyuezhang exosomeincrosstalkbetweeninflammationandangiogenesisapotentialtherapeuticstrategyforstroke |