Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels
This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were d...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/4138696 |
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| author | Lianlong Yu Jingyi Yan Qian Zhang Hong Lin Lichao Zhu Qiangqiang Liu Changsheng Zhao |
| author_facet | Lianlong Yu Jingyi Yan Qian Zhang Hong Lin Lichao Zhu Qiangqiang Liu Changsheng Zhao |
| author_sort | Lianlong Yu |
| collection | DOAJ |
| description | This study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P<0.05). But HDL-C was just the opposite (P<0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P<0.05). And, HDL-C was just the opposite (P<0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P<0.05). But the correlation between LDL-C and ferritin was broken (P>0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders. |
| format | Article |
| id | doaj-art-11554a4c8d144777a5f89ac4066592f4 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-11554a4c8d144777a5f89ac4066592f42025-08-20T03:54:11ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/41386964138696Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP LevelsLianlong Yu0Jingyi Yan1Qian Zhang2Hong Lin3Lichao Zhu4Qiangqiang Liu5Changsheng Zhao6Institution of Food and Nutrition, Shandong Center for Disease Control and Prevention, Ji’nan, Shandong, ChinaInstitution of Food and Nutrition, Shandong Center for Disease Control and Prevention, Ji’nan, Shandong, ChinaLaw Enforcement and Supervision Bureau of Shandong Provincial Health Commission, Ji’nan, Shandong, ChinaQianfoshan Hospital, Ji’nan, Shandong, ChinaDepartment of Pediatric Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Ji’nan, Shandong, ChinaDepartment of General Practice, Qilu Hospital of Shandong University, Ji’nan, Shandong, ChinaDepartment of Nutriology, The Second Hospital of Shandong University, Ji’nan, Shandong, ChinaThis study is aimed at exploring the relationship between serum ferritin and blood lipids and the influence of diabetes and different hs-CRP levels. A total of 8163 subjects were analyzed. Participators were classified according to serum ferritin, diabetes, and two hs-CRP levels. Blood lipids were determined using standardized methods and conditions. Except for HDL-C, there was a significant increase in blood lipids in the progressive ferritin group with normal hs-CRP levels (P<0.05). But HDL-C was just the opposite (P<0.0001). In nondiabetic patients, TG, TC, and LDL-C were significantly elevated in the progressive ferritin group (P<0.05). And, HDL-C was just the opposite (P<0.05). The generalized linear model and the parsimonious model showed that serum TG was positively correlated with ferritin, and LDL-C was negatively correlated with ferritin (P<0.05). But the correlation between LDL-C and ferritin was broken (P>0.05). After a sufficient adjustment, there was a positive correlation between serum TG and ferritin and a negative correlation between LDL-C and ferritin. Nonetheless, a negative correlation between LDL-C and ferritin is influenced by diabetes frailly. And, there was no change of relationship between lipids and ferritin in different hs-CRP levels. We found a real relationship between ferritin and lipids after sufficient adjustment for confounders.http://dx.doi.org/10.1155/2020/4138696 |
| spellingShingle | Lianlong Yu Jingyi Yan Qian Zhang Hong Lin Lichao Zhu Qiangqiang Liu Changsheng Zhao Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels Journal of Diabetes Research |
| title | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
| title_full | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
| title_fullStr | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
| title_full_unstemmed | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
| title_short | Association between Serum Ferritin and Blood Lipids: Influence of Diabetes and hs-CRP Levels |
| title_sort | association between serum ferritin and blood lipids influence of diabetes and hs crp levels |
| url | http://dx.doi.org/10.1155/2020/4138696 |
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