PPI-Graphomer: enhanced protein-protein affinity prediction using pretrained and graph transformer models

PPI-Graphomer: enhanced protein-protein affinity prediction using pretrained and graph transformer models

Abstract Protein-protein interactions (PPIs) refer to the phenomenon of protein binding through various types of bonds to execute biological functions. These interactions are critical for understanding biological mechanisms and drug research. Among these, the protein binding interface is a critical...

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Bibliographic Details
Main Authors: Jun Xie, Youli Zhang, Ziyang Wang, Xiaocheng Jin, Xiaoli Lu, Shengxiang Ge, Xiaoping Min
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Bioinformatics
Subjects:
Bind affinity prediction
ESM
Graph transformer
Online Access:https://doi.org/10.1186/s12859-025-06123-2
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