Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine Doelings
This study investigated the effects of prenatal herbal methionine supplementation on growth, puberty onset, reproductive efficiency, and blood metabolites in first-generation G1 Alpine doelings. Sixty pregnant multiparous goats (G0), each with at least three parturitions, were assigned during the la...
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MDPI AG
2025-02-01
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| author | Venancio Cuevas-Reyes Jorge Flores-Sánchez Esau Ramírez de la Cruz Juan M. Vázquez-García Luisa E. S. Hernández-Arteaga Reagan Sims Jaime M. Cavazos-Galindo Miguel Mellado César A. Rosales-Nieto |
| author_facet | Venancio Cuevas-Reyes Jorge Flores-Sánchez Esau Ramírez de la Cruz Juan M. Vázquez-García Luisa E. S. Hernández-Arteaga Reagan Sims Jaime M. Cavazos-Galindo Miguel Mellado César A. Rosales-Nieto |
| author_sort | Venancio Cuevas-Reyes |
| collection | DOAJ |
| description | This study investigated the effects of prenatal herbal methionine supplementation on growth, puberty onset, reproductive efficiency, and blood metabolites in first-generation G1 Alpine doelings. Sixty pregnant multiparous goats (G0), each with at least three parturitions, were assigned during the last trimester of pregnancy to either herbal methionine (H-MET-G0; 1% Optimethione<sup>®</sup>; n = 30) or a control group (CTL-G0; n = 30). Only female offspring (G1 doelings) were studied (H-MET-G1:19; CTL-G1:25) from weaning (45 days old) to 10 months (first breeding). G1 doelings were weighed and monitored weekly for metabolites, IGF-1, insulin, and progesterone. Ovulation of the G1 doelings was induced using vasectomized bucks, followed by breeding with intact bucks. Postweaning growth, age at puberty (H-MET-G1:216 vs. CTL-G1:229 days), and live weight at puberty (H-MET-G1:20.5 vs. CTL-G1:21.0 kg) did not significantly differ (<i>p</i> > 0.05). Age at puberty and conception were negatively correlated with live weight (<i>p</i> < 0.001). First-cycle conception rates were 81% in CTL-G1 and 66% in H-MET-G1, with similar days to conception (<i>p</i> > 0.05). The number of pregnant doelings and the number of kids in utero did not significantly differ (<i>p</i> > 0.05) between treatments. Plasma IGF-1 and insulin levels were significantly higher (<i>p</i> < 0.001) in H-MET-G1 doelings, whereas plasma metabolites related to nutrition showed no differences between groups (<i>p</i> > 0.05). Prenatal herbal methionine supplementation had no carry-over effect on growth, puberty onset, or reproductive efficiency. Age at puberty and conception were negatively correlated with live weight and positively correlated with IGF-1 and insulin levels. |
| format | Article |
| id | doaj-art-114a9665f6ea418bb1cea12f3f4613c7 |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-114a9665f6ea418bb1cea12f3f4613c72025-08-20T03:43:30ZengMDPI AGBiology2079-77372025-02-0114323710.3390/biology14030237Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine DoelingsVenancio Cuevas-Reyes0Jorge Flores-Sánchez1Esau Ramírez de la Cruz2Juan M. Vázquez-García3Luisa E. S. Hernández-Arteaga4Reagan Sims5Jaime M. Cavazos-Galindo6Miguel Mellado7César A. Rosales-Nieto8Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Campo Experimental Valle de México, Texcoco 56250, MexicoLaboratorio de Especialidades Médicas, Facultad de Medicina, Universidad Autónoma San Luis Potosí, San Luis Potosí 78290, MexicoFacultad de Agronomía y Veterinaria, Universidad Autónoma San Luis Potosí, San Luis Potosí 78321, MexicoFacultad de Agronomía y Veterinaria, Universidad Autónoma San Luis Potosí, San Luis Potosí 78321, MexicoFacultad de Agronomía y Veterinaria, Universidad Autónoma San Luis Potosí, San Luis Potosí 78321, MexicoDepartment of Agricultural Sciences, Texas State University, San Marcos, TX 78666, USACentro de Fomento Ganadero Vallecillo, Universidad Autónoma de Nuevo León, Vallecillo 65415, MexicoDepartamento de Nutrición Animal, Universidad Autónoma Agraria Antonio Narro, Saltillo 25315, MexicoFacultad de Agronomía y Veterinaria, Universidad Autónoma San Luis Potosí, San Luis Potosí 78321, MexicoThis study investigated the effects of prenatal herbal methionine supplementation on growth, puberty onset, reproductive efficiency, and blood metabolites in first-generation G1 Alpine doelings. Sixty pregnant multiparous goats (G0), each with at least three parturitions, were assigned during the last trimester of pregnancy to either herbal methionine (H-MET-G0; 1% Optimethione<sup>®</sup>; n = 30) or a control group (CTL-G0; n = 30). Only female offspring (G1 doelings) were studied (H-MET-G1:19; CTL-G1:25) from weaning (45 days old) to 10 months (first breeding). G1 doelings were weighed and monitored weekly for metabolites, IGF-1, insulin, and progesterone. Ovulation of the G1 doelings was induced using vasectomized bucks, followed by breeding with intact bucks. Postweaning growth, age at puberty (H-MET-G1:216 vs. CTL-G1:229 days), and live weight at puberty (H-MET-G1:20.5 vs. CTL-G1:21.0 kg) did not significantly differ (<i>p</i> > 0.05). Age at puberty and conception were negatively correlated with live weight (<i>p</i> < 0.001). First-cycle conception rates were 81% in CTL-G1 and 66% in H-MET-G1, with similar days to conception (<i>p</i> > 0.05). The number of pregnant doelings and the number of kids in utero did not significantly differ (<i>p</i> > 0.05) between treatments. Plasma IGF-1 and insulin levels were significantly higher (<i>p</i> < 0.001) in H-MET-G1 doelings, whereas plasma metabolites related to nutrition showed no differences between groups (<i>p</i> > 0.05). Prenatal herbal methionine supplementation had no carry-over effect on growth, puberty onset, or reproductive efficiency. Age at puberty and conception were negatively correlated with live weight and positively correlated with IGF-1 and insulin levels.https://www.mdpi.com/2079-7737/14/3/237doelingreproductiongrowthage and liveweight at pubertyAlpine |
| spellingShingle | Venancio Cuevas-Reyes Jorge Flores-Sánchez Esau Ramírez de la Cruz Juan M. Vázquez-García Luisa E. S. Hernández-Arteaga Reagan Sims Jaime M. Cavazos-Galindo Miguel Mellado César A. Rosales-Nieto Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine Doelings Biology doeling reproduction growth age and liveweight at puberty Alpine |
| title | Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine Doelings |
| title_full | Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine Doelings |
| title_fullStr | Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine Doelings |
| title_full_unstemmed | Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine Doelings |
| title_short | Effects of Prenatal Herbal Methionine Supplementation on Growth Indices, Onset of Puberty, Blood Metabolites, and Fertility of Alpine Doelings |
| title_sort | effects of prenatal herbal methionine supplementation on growth indices onset of puberty blood metabolites and fertility of alpine doelings |
| topic | doeling reproduction growth age and liveweight at puberty Alpine |
| url | https://www.mdpi.com/2079-7737/14/3/237 |
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