Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma

Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway. Recent biologic insights and therapeutic targeting of MAPK-alterations have dramatically shifted the treatment app...

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Bibliographic Details
Main Authors: Erin E. Crotty, Aimee A. Sato, Mohamed S. Abdelbaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Oncology
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Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1520316/full
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