Ketogenic therapy for schizophrenia: evidence, mechanisms, and clinical perspectives

Ketogenic therapy for schizophrenia: evidence, mechanisms, and clinical perspectives

IntroductionSchizophrenia is a chronic psychiatric disorder marked by significant cognitive and functional impairments. Current antipsychotic treatments offer limited benefit for negative symptoms and cognitive dysfunction while often exacerbating metabolic comorbidities. Emerging evidence implicate...

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Bibliographic Details
Main Authors: Cristiano Chaves, Jennifer Fabe, Fabiano A. Gomes, Heather McNeely, Massimo Tusconi, Mauro Giovanni Carta, Serdar M. Dursun, Jaime E. C. Hallak, Elisa Brietzke
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
schizophrenia
ketogenic metabolic therapy (KMT)
mitochondrial dysfunction
glucose metabolism
cognitive impairment
treatment resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1603722/full
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